Assay Detail
Binding
CHEMBL5442202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PDSP Secondary Binding target: HTR2C - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Category | PDSP assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - PDSP Secondary Binding
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 6.32 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 8.39 |
| CHEMBL4743049 | — | — | 1 | 8.03 |
| CHEMBL1489369 | — | — | 1 | 7.51 |
| CHEMBL83894 | FANANSERIN | 2.0 | 1 | 7.30 |
| CHEMBL2105760 | BREXPIPRAZOLE | 4.0 | 1 | 7.22 |
| CHEMBL74355 | VOLINANSERIN | 3.0 | 1 | 6.94 |
| CHEMBL567303 | PALOSURAN | 2.0 | 1 | 6.86 |
| CHEMBL1516474 | TEGASEROD MALEATE | 4.0 | 1 | 6.85 |
| CHEMBL2107572 | TECALCET HYDROCHLORIDE | 2.0 | 1 | 6.79 |
| CHEMBL5075931 | — | — | 1 | 6.75 |
| CHEMBL1633 | KETOTIFEN FUMARATE | 4.0 | 1 | 6.71 |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | 4.0 | 1 | 6.67 |
| CHEMBL103769 | — | — | 1 | 6.60 |
| CHEMBL1200492 | NEFAZODONE HYDROCHLORIDE | 4.0 | 1 | 6.60 |
| CHEMBL5089005 | — | — | 1 | 6.58 |
| CHEMBL259656 | — | — | 1 | 6.50 |
| CHEMBL531742 | — | — | 1 | 6.48 |
| CHEMBL540612 | — | — | 1 | 6.23 |
| CHEMBL1256998 | — | — | 1 | 6.20 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | 4.0 | 1 | 6.18 |
| CHEMBL281350 | SB-224289 | — | 1 | 6.07 |
| CHEMBL214957 | — | — | 1 | 6.05 |
| CHEMBL1256863 | — | — | 1 | 5.97 |
| CHEMBL3215877 | — | — | 1 | 5.93 |
| CHEMBL2024517 | CARIPRAZINE HYDROCHLORIDE | 4.0 | 1 | 5.90 |
| CHEMBL542139 | — | — | 1 | 5.89 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | 4.0 | 1 | 5.86 |
| CHEMBL1215661 | PRUVANSERIN | 2.0 | 1 | 5.83 |
| CHEMBL1095777 | INDACATEROL | 4.0 | 1 | 5.75 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | Ki | = | 4.09 | nM | 8.39 |
| CHEMBL4743049 | — | Ki | = | 9.447 | nM | 8.03 |
| CHEMBL1489369 | — | Ki | = | 30.55 | nM | 7.51 |
| CHEMBL83894 | FANANSERIN | Ki | = | 49.98 | nM | 7.30 |
| CHEMBL2105760 | BREXPIPRAZOLE | Ki | = | 60.48 | nM | 7.22 |
| CHEMBL74355 | VOLINANSERIN | Ki | = | 113.89 | nM | 6.94 |
| CHEMBL567303 | PALOSURAN | Ki | = | 138.8 | nM | 6.86 |
| CHEMBL1516474 | TEGASEROD MALEATE | Ki | = | 141.51 | nM | 6.85 |
| CHEMBL2107572 | TECALCET HYDROCHLORIDE | Ki | = | 162.26 | nM | 6.79 |
| CHEMBL5075931 | — | Ki | = | 176.64 | nM | 6.75 |
| CHEMBL1633 | KETOTIFEN FUMARATE | Ki | = | 197.38 | nM | 6.71 |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | Ki | = | 214.19 | nM | 6.67 |
| CHEMBL103769 | — | Ki | = | 251.45 | nM | 6.60 |
| CHEMBL1200492 | NEFAZODONE HYDROCHLORIDE | Ki | = | 253.05 | nM | 6.60 |
| CHEMBL5089005 | — | Ki | = | 263.51 | nM | 6.58 |
| CHEMBL259656 | — | Ki | = | 319.12 | nM | 6.50 |
| CHEMBL531742 | — | Ki | = | 328.25 | nM | 6.48 |
| CHEMBL540612 | — | Ki | = | 583.51 | nM | 6.23 |
| CHEMBL1256998 | — | Ki | = | 635.26 | nM | 6.20 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | Ki | = | 658.04 | nM | 6.18 |
| CHEMBL281350 | SB-224289 | Ki | = | 859.31 | nM | 6.07 |
| CHEMBL214957 | — | Ki | = | 893.2 | nM | 6.05 |
| CHEMBL1256863 | — | Ki | = | 1062.92 | nM | 5.97 |
| CHEMBL3215877 | — | Ki | = | 1180.05 | nM | 5.93 |
| CHEMBL2024517 | CARIPRAZINE HYDROCHLORIDE | Ki | = | 1253.72 | nM | 5.90 |
| CHEMBL542139 | — | Ki | = | 1281.74 | nM | 5.89 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | Ki | = | 1373.1 | nM | 5.86 |
| CHEMBL1215661 | PRUVANSERIN | Ki | = | 1472.65 | nM | 5.83 |
| CHEMBL1095777 | INDACATEROL | Ki | = | 1800.32 | nM | 5.75 |
| CHEMBL405355 | NIGULDIPINE | Ki | = | 1854.81 | nM | 5.73 |
| CHEMBL4164059 | PITOLISANT HYDROCHLORIDE | Ki | = | 1987.93 | nM | 5.70 |
| CHEMBL3342358 | — | Ki | = | 2215.65 | nM | 5.65 |
| CHEMBL23327 | PURVALANOLA | Ki | = | 3035.29 | nM | 5.52 |
| CHEMBL1235246 | — | Ki | = | 3076.45 | nM | 5.51 |
| CHEMBL191 | LOSARTAN | Ki | = | 3493.01 | nM | 5.46 |
| CHEMBL1263 | SALMETEROL | Ki | = | 4092.61 | nM | 5.39 |
| CHEMBL344159 | TOLVAPTAN | Ki | = | 4856.23 | nM | 5.31 |
| CHEMBL1705 | CLONIDINE HYDROCHLORIDE | Ki | = | 6953.44 | nM | 5.16 |