Compound Detail
CHEMBL1263
SALMETEROL 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1263 |
| Name | SALMETEROL |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | GIIZNNXWQWCKIB-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
30
Targets
109
Activities
4
Assay Types
9
PK Parameters
20
Publications
5
Known Names
8
Indications
Molecular Properties
415.6
MW (Da)
4.11
ALogP
5
HBA
4
HBD
82.0
PSA (Ų)
0.31
QED
0
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1994 |
| Availability | Prescription |
| Chirality | Racemic |
Indications
Lung Diseases, Obstructive Asthma Bronchiolitis Obliterans Bronchitis, Chronic Emphysema Pulmonary Disease, Chronic Obstructive Lung Diseases Spinal Cord Injuries
ATC Classification
R03AC12
salmeterol
Level 1: RESPIRATORY SYSTEM
Level 2: DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Activity Summary
EC50 59 meas. best 10.35
Ki 35 meas. best 9.74
IC50 13 meas. best 8.46
Kd 2 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-2 adrenergic receptor CHEMBL210 | EC50 | 10.35 | 9.6237 | 0.0 | 27 |
| Beta-2 adrenergic receptor CHEMBL210 | Ki | 9.74 | 8.6975 | 0.2 | 12 |
| Beta-2 adrenergic receptor CHEMBL210 | Kd | 9.52 | 7.74 | 0.3 | 2 |
| Beta-2 adrenergic receptor CHEMBL5414 | EC50 | 8.57 | 8.1675 | 2.7 | 4 |
| Beta-2 adrenergic receptor CHEMBL5414 | IC50 | 8.46 | 8.46 | 3.5 | 2 |
| Unchecked CHEMBL612545 | EC50 | 8.3 | 8.23 | 5.0 | 2 |
| Beta-1 adrenergic receptor CHEMBL5471 | EC50 | 8.3 | 8.3 | 5.0 | 1 |
| Beta-2 adrenergic receptor CHEMBL210 | IC50 | 8.3 | 8.065 | 5.0 | 2 |
| Oryctolagus cuniculus CHEMBL374 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| Beta-1 adrenergic receptor CHEMBL213 | EC50 | 7.53 | 6.3713 | 29.5 | 16 |
| Sigma intracellular receptor 2 CHEMBL4105907 | Ki | 7.49 | 7.49 | 32.4 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 6.83 | 6.83 | 149.4 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 6.59 | 6.59 | 256.9 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 6.53 | 6.53 | 294.2 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | Ki | 6.42 | 6.42 | 381.9 | 1 |
| Beta-1 adrenergic receptor CHEMBL213 | IC50 | 6.3 | 6.3 | 501.2 | 2 |
| Beta-1 adrenergic receptor CHEMBL3440 | Ki | 6.26 | 6.26 | 550.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL229 | Ki | 6.26 | 6.26 | 548.7 | 1 |
| dengue virus type 2 CHEMBL613966 | IC50 | 6.17 | 6.17 | 670.0 | 1 |
| Beta-1 adrenergic receptor CHEMBL213 | Ki | 6.16 | 5.922 | 694.5 | 5 |
| Alpha-1D adrenergic receptor CHEMBL223 | Ki | 6.02 | 6.02 | 963.2 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | Ki | 6.01 | 6.01 | 971.3 | 1 |
| Beta-3 adrenergic receptor CHEMBL246 | EC50 | 6.0 | 5.9286 | 1000.0 | 7 |
| 5-hydroxytryptamine receptor 1D CHEMBL1983 | Ki | 5.99 | 5.99 | 1036.3 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 5.98 | 5.94 | 1049.0 | 2 |
| D(4) dopamine receptor CHEMBL219 | Ki | 5.97 | 5.97 | 1076.3 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 5.89 | 5.89 | 1274.8 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 5.71 | 5.71 | 1942.9 | 1 |
| 5-hydroxytryptamine receptor 1B CHEMBL1898 | Ki | 5.7 | 5.7 | 1985.4 | 1 |
| Psychosine receptor CHEMBL3714081 | IC50 | 5.61 | 5.61 | 2463.2 | 1 |
| CX3C chemokine receptor 1 CHEMBL4843 | IC50 | 5.5 | 5.5 | 3138.6 | 1 |
| Adhesion G-protein coupled receptor F1 CHEMBL4523872 | IC50 | 5.47 | 5.47 | 3409.7 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 5.39 | 5.39 | 4092.6 | 1 |
| G-protein coupled receptor 183 CHEMBL3259470 | IC50 | 5.37 | 5.37 | 4255.5 | 1 |
| N-formyl peptide receptor 3 CHEMBL5646 | IC50 | 5.25 | 5.25 | 5657.9 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 4.5 | 4.5 | 32000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 58.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 85.0 | uL.min-1.(10^6cells)-1 | Rattus norvegicus |
| F | 10.0 | % | Rattus norvegicus |
| F | 10.0 | % | Rattus norvegicus |
| F | 66.0 | % | Canis lupus familiaris |
| F | 10.0 | % | Rattus norvegicus |
| F | 66.0 | % | Canis lupus familiaris |
| T1/2 | 2.9 | hr | Rattus norvegicus |
| T1/2 | 2.9 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine