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Assay Detail

CHEMBL4843198

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL ↗
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-2 adrenergic receptor (CHEMBL210) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

8-Hydroxyquinolin-2(1H)-one analogues as potential β<sub>2</sub>-agonists: Design, synthesis and activity study.
Xing G, Zhi Z, Yi C, Zou J, Jing X, Yiu-Ho Woo A, Lin B, Pan L, Zhang Y, Cheng M.
Eur J Med Chem (2021) 224 : 113697 -113697
PubMed 34273662 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 39 10.53 10.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4847536 — — 1 10.97
CHEMBL4871708 — — 1 10.90
CHEMBL4873082 — — 1 10.89
CHEMBL4848793 — — 1 10.87
CHEMBL4854569 — — 1 10.83
CHEMBL4865710 — — 1 10.78
CHEMBL4848018 — — 1 10.76
CHEMBL4862449 — — 1 10.75
CHEMBL4848704 — — 1 10.75
CHEMBL4868938 — — 1 10.74
CHEMBL4854261 — — 1 10.74
CHEMBL4860454 — — 1 10.74
CHEMBL4855974 — — 1 10.71
CHEMBL4872480 — — 1 10.67
CHEMBL4863282 — — 1 10.67
CHEMBL4857267 — — 1 10.65
CHEMBL4868585 — — 1 10.65
CHEMBL4868684 — — 1 10.63
CHEMBL4846631 — — 1 10.61
CHEMBL4863847 — — 1 10.58
CHEMBL4868763 — — 1 10.55
CHEMBL4872653 — — 1 10.55
CHEMBL4848617 — — 1 10.54
CHEMBL4848775 — — 1 10.51
CHEMBL4853372 — — 1 10.48
CHEMBL4860764 — — 1 10.47
CHEMBL4866766 — — 1 10.44
CHEMBL4865833 — — 1 10.42
CHEMBL4870623 — — 1 10.42
CHEMBL4865514 — — 1 10.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4847536 — EC50 = 0.01072 nM 10.97
CHEMBL4871708 — EC50 = 0.01259 nM 10.90
CHEMBL4873082 — EC50 = 0.01288 nM 10.89
CHEMBL4848793 — EC50 = 0.01349 nM 10.87
CHEMBL4854569 — EC50 = 0.01479 nM 10.83
CHEMBL4865710 — EC50 = 0.0166 nM 10.78
CHEMBL4848018 — EC50 = 0.01738 nM 10.76
CHEMBL4862449 — EC50 = 0.01778 nM 10.75
CHEMBL4848704 — EC50 = 0.01778 nM 10.75
CHEMBL4860454 — EC50 = 0.0182 nM 10.74
CHEMBL4854261 — EC50 = 0.0182 nM 10.74
CHEMBL4868938 — EC50 = 0.0182 nM 10.74
CHEMBL4855974 — EC50 = 0.0195 nM 10.71
CHEMBL4872480 — EC50 = 0.02138 nM 10.67
CHEMBL4863282 — EC50 = 0.02138 nM 10.67
CHEMBL4857267 — EC50 = 0.02239 nM 10.65
CHEMBL4868585 — EC50 = 0.02239 nM 10.65
CHEMBL4868684 — EC50 = 0.02344 nM 10.63
CHEMBL4846631 — EC50 = 0.02455 nM 10.61
CHEMBL4863847 — EC50 = 0.0263 nM 10.58
CHEMBL4872653 — EC50 = 0.02818 nM 10.55
CHEMBL4868763 — EC50 = 0.02818 nM 10.55
CHEMBL4848617 — EC50 = 0.02884 nM 10.54
CHEMBL4848775 — EC50 = 0.0309 nM 10.51
CHEMBL4853372 — EC50 = 0.03311 nM 10.48
CHEMBL4860764 — EC50 = 0.03388 nM 10.47
CHEMBL4866766 — EC50 = 0.03631 nM 10.44
CHEMBL4865833 — EC50 = 0.03802 nM 10.42
CHEMBL4870623 — EC50 = 0.03802 nM 10.42
CHEMBL4865514 — EC50 = 0.04467 nM 10.35
CHEMBL4874945 — EC50 = 0.04677 nM 10.33
CHEMBL4859591 — EC50 = 0.05754 nM 10.24
CHEMBL4847767 — EC50 = 0.07244 nM 10.14
CHEMBL4867311 — EC50 = 0.08318 nM 10.08
CHEMBL605846 OLODATEROL EC50 = 0.0871 nM 10.06
CHEMBL4873280 — EC50 = 0.0955 nM 10.02
CHEMBL1263 SALMETEROL EC50 = 0.1349 nM 9.87
CHEMBL434 ISOPROTERENOL EC50 = 0.2138 nM 9.67
CHEMBL4856990 — EC50 = 0.00631 nM -