Assay Detail
Functional
CHEMBL889143
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Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The discovery of long acting beta2-adrenoreceptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 10.22 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230486 | — | — | 1 | 10.70 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 10.15 |
| CHEMBL230203 | — | — | 1 | 10.02 |
| CHEMBL230487 | — | — | 1 | 10.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230486 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL230203 | — | EC50 | = | 0.096 | nM | 10.02 |
| CHEMBL230487 | — | EC50 | = | 0.096 | nM | 10.02 |