Assay Detail
Functional
CHEMBL1019681
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Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 8.75 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443435 | — | — | 1 | 9.80 |
| CHEMBL446840 | — | — | 1 | 9.80 |
| CHEMBL500782 | — | — | 1 | 9.70 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 9.60 |
| CHEMBL475389 | — | — | 1 | 9.30 |
| CHEMBL514032 | — | — | 1 | 9.30 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 9.30 |
| CHEMBL516056 | — | — | 1 | 9.20 |
| CHEMBL520313 | — | — | 1 | 9.10 |
| CHEMBL474393 | — | — | 1 | 9.00 |
| CHEMBL506518 | — | — | 1 | 9.00 |
| CHEMBL456485 | — | — | 1 | 8.90 |
| CHEMBL475237 | — | — | 1 | 8.80 |
| CHEMBL485847 | — | — | 1 | 8.60 |
| CHEMBL483202 | — | — | 1 | 8.10 |
| CHEMBL475236 | — | — | 1 | 8.00 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.40 |
| CHEMBL483407 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443435 | — | EC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL446840 | — | EC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL500782 | — | EC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL475389 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL514032 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL516056 | — | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL520313 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL474393 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL506518 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL456485 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL475237 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL485847 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL483202 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL475236 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL483407 | — | EC50 | = | 25118.86 | nM | 4.60 |