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Compound Detail

CHEMBL506518

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CC(=O)O.O=S(=O)(c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1)N1CCCCC1

Basic Information

ChEMBL ID CHEMBL506518
Phase Preclinical
Structure Type MOL
InChI Key ASGWGXWBDRYNIF-CZCBIWLKSA-N
Parent Compound CHEMBL1187520
Active Moiety CHEMBL1187520
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

562.8
MW (Da)
4.28
ALogP
7
HBA
4
HBD
119.3
PSA (Ų)
0.20
QED
1
Ro5 Violations
18
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H50N2O8S
MW 622.83
Aromatic Rings 2
Heavy Atoms 39
NP-Likeness -0.54

Activity Summary

EC50 5 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.0 9.0 1.0 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.9 6.9 125.9 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 6.8 6.8 158.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19317397 10.1021/jm801016j Beta-2 adrenergic receptor 2
19317397 10.1021/jm801016j Unchecked 2
19317397 10.1021/jm801016j Beta-1 adrenergic receptor 1
19317397 10.1021/jm801016j Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine