Assay Detail
Functional
CHEMBL1019683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human cloned beta3 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.27 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 7.60 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.40 |
| CHEMBL500782 | — | — | 1 | 7.30 |
| CHEMBL506518 | — | — | 1 | 6.80 |
| CHEMBL443435 | — | — | 1 | 6.70 |
| CHEMBL514032 | — | — | 1 | 6.50 |
| CHEMBL485847 | — | — | 1 | 6.50 |
| CHEMBL520313 | — | — | 1 | 6.30 |
| CHEMBL456485 | — | — | 1 | 6.20 |
| CHEMBL474393 | — | — | 1 | 6.20 |
| CHEMBL516056 | — | — | 1 | 6.10 |
| CHEMBL475389 | — | — | 1 | 5.90 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 5.90 |
| CHEMBL446840 | — | — | 1 | 5.80 |
| CHEMBL483407 | — | — | 1 | 5.70 |
| CHEMBL483202 | — | — | 1 | 5.60 |
| CHEMBL475237 | — | — | 1 | 5.60 |
| CHEMBL475236 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL500782 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL506518 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL443435 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL514032 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL485847 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL520313 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL456485 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL474393 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL516056 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL475389 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL446840 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL483407 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL483202 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL475237 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL475236 | — | EC50 | = | 19952.62 | nM | 4.70 |