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Compound Detail

CHEMBL475237

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NS(=O)(=O)Cc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1

Basic Information

ChEMBL ID CHEMBL475237
Phase Preclinical
Structure Type MOL
InChI Key ZXQIEANXCQRVSZ-SANMLTNESA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

508.7
MW (Da)
2.90
ALogP
7
HBA
5
HBD
142.1
PSA (Ų)
0.19
QED
1
Ro5 Violations
18
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H40N2O6S
MW 508.68
Aromatic Rings 2
Heavy Atoms 35
NP-Likeness -0.16

Activity Summary

EC50 5 meas. best 8.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.8 8.8 1.6 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.0 6.0 1000.0 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 5.6 5.6 2511.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19317397 10.1021/jm801016j Beta-2 adrenergic receptor 2
19317397 10.1021/jm801016j Unchecked 2
19317397 10.1021/jm801016j Beta-1 adrenergic receptor 1
19317397 10.1021/jm801016j Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine