Beta-1 adrenergic receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Beta-1 adrenergic receptor shows approved-linked disease relevance led by hypertension. 5 more disease programs remain visible in the same review block. 10 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P08588. Start with hypertension, then reuse UniProt P08588 as the stable protein anchor across project notes and exports.
Start with hypertension, then reuse UniProt P08588 as the stable protein anchor across project notes and exports.
Beta-1 adrenergic receptor shows approved-linked disease relevance led by hypertension. 5 more disease programs remain visible in the same review block. 10 linked drugs remain visible in the same block.
Start review with hypertension because it currently carries approved-linked support. Linked drugs include ACEBUTOLOL HYDROCHLORIDE, ATENOLOL, BETAXOLOL HYDROCHLORIDE, BISOPROLOL FUMARATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyBeta-1 adrenergic receptor
Review this target as Beta-1 adrenergic receptor, mapped to UniProt P08588. Sequence length is 477 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Beta-1 adrenergic receptor as ChEMBL target CHEMBL213, mapped to UniProt P08588. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Beta-1 adrenergic receptor is the right protein anchor across sources, using UniProt P08588 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hypertension is currently framed as approved-linked support. It currently carries 10 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Beta-1 adrenergic receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08588 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Beta-1 adrenergic receptor |
| UniProt Accession | P08588 |
| Component Type | Protein |
| Sequence Length | 477 aa |
Beta-1 adrenergic receptor
Review this target as Beta-1 adrenergic receptor, mapped to UniProt P08588. Sequence length is 477 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Beta-1 adrenergic receptor shows approved-linked disease relevance led by hypertension. 5 more disease programs remain visible in the same review block.
Start review with hypertension because it currently carries approved-linked support. Linked drugs include ACEBUTOLOL HYDROCHLORIDE, ATENOLOL, BETAXOLOL HYDROCHLORIDE, BISOPROLOL FUMARATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2012522 | 10.64 | Ki | 0.023 | Preclinical |
| CHEMBL2011218 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL2011227 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL2011226 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL5207281 | 10.12 | Kd | 0.075 | Preclinical |
| CHEMBL5201074 | 10.12 | Kd | 0.075 | Preclinical |
| CHEMBL4860528 | 10.12 | Kd | 0.075 | Preclinical |
| CHEMBL5206565 | 10.12 | Kd | 0.075 | Preclinical |
| CHEMBL2011216 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL434 | 10.08 | EC50 | 0.084 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 315 | 255 | 6.7 |
| cell-based format | 106 | 621 | 6.1 |
| assay format | 5 | 32 | 7.7 |
| cell membrane format | 4 | 64 | 6.3 |
| organism-based format | 1 | 1 | 7.3 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 136 | 655 | 7.2 |
| assay format | 78 | 50 | 6.6 |
| tissue-based format | 4 | 0 | — |
| organism-based format | 3 | 0 | — |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 40 | 7.5 |
| single protein format | 4 | 0 | — |