Compound Detail
CHEMBL2105743
OLODATEROL HYDROCHLORIDE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL2105743 |
| Name | OLODATEROL HYDROCHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | KCEHVJZZIGJAAW-FERBBOLQSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL605846 |
| Active Moiety | CHEMBL605846 |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
5
Known Names
3
Indications
1
Mechanisms
Molecular Properties
386.4
MW (Da)
2.38
ALogP
6
HBA
4
HBD
100.0
PSA (Ų)
0.58
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2014 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Beta-2 adrenergic receptor agonist | AGONIST | Beta-2 adrenergic receptor | ✓ | ✓ |
Indications
Bronchitis, Chronic Emphysema Pulmonary Disease, Chronic Obstructive
Activity Summary
EC50 2 meas. best 7.56
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-1 adrenergic receptor CHEMBL213 | EC50 | 7.56 | 7.56 | 27.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | EC50 | = | 27.54 | nM | 7.56 | Agonist activity at human beta1 adrenoreceptor overexpressed in human HEK293 cel... | 31753798 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31753798 | 10.1016/j.bmc.2019.115178 | Unchecked | 5 |
| 31753798 | 10.1016/j.bmc.2019.115178 | Beta-2 adrenergic receptor | 2 |
| 31753798 | 10.1016/j.bmc.2019.115178 | Beta-1 adrenergic receptor | 1 |
Data from ChEMBL 36 via Core Engine