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Compound Detail

CHEMBL483202

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CC(=O)O.NS(=O)(=O)c1cccc(CCCCCOCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1

Basic Information

ChEMBL ID CHEMBL483202
Phase Preclinical
Structure Type MOL
InChI Key JPNFPRCTENJMGY-UQIIZPHYSA-N
Parent Compound CHEMBL1186940
Active Moiety CHEMBL1186940
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

494.6
MW (Da)
2.75
ALogP
7
HBA
5
HBD
142.1
PSA (Ų)
0.21
QED
0
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H42N2O8S
MW 554.71
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness -0.28

Activity Summary

EC50 5 meas. best 8.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 8.1 8.1 7.9 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 5.9 5.9 1258.9 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 5.6 5.6 2511.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19317397 10.1021/jm801016j Beta-2 adrenergic receptor 2
19317397 10.1021/jm801016j Unchecked 2
19317397 10.1021/jm801016j Beta-1 adrenergic receptor 1
19317397 10.1021/jm801016j Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine