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Compound Detail

CHEMBL514032

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CC(=O)O.CC(C)NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1

Basic Information

ChEMBL ID CHEMBL514032
Phase Preclinical
Structure Type MOL
InChI Key KGLPPDRMRKNOLZ-JCOPYZAKSA-N
Parent Compound CHEMBL1187654
Active Moiety CHEMBL1187654
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

536.7
MW (Da)
3.79
ALogP
7
HBA
5
HBD
128.1
PSA (Ų)
0.17
QED
1
Ro5 Violations
19
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H48N2O8S
MW 596.79
Aromatic Rings 2
Heavy Atoms 37
NP-Likeness -0.42

Activity Summary

EC50 6 meas. best 9.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.3 9.3 0.5 1
Beta-1 adrenergic receptor
CHEMBL5471
EC50 8.0 8.0 10.0 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 6.5 6.5 316.2 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.0 6.0 1000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19317397 10.1021/jm801016j Beta-1 adrenergic receptor 5
19317397 10.1021/jm801016j Beta-2 adrenergic receptor 2
19317397 10.1021/jm801016j Unchecked 2
19317397 10.1021/jm801016j Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine