Assay Detail
Functional
CHEMBL1019684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at beta-1 adrenergic receptor in guinea pig trachea assessed as inhibition of electrical stimulation-induced muscle contraction
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.90 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443435 | — | — | 1 | 10.40 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 9.50 |
| CHEMBL483200 | — | — | 1 | 9.10 |
| CHEMBL475389 | — | — | 1 | 8.70 |
| CHEMBL520313 | — | — | 1 | 8.60 |
| CHEMBL474616 | — | — | 1 | 8.60 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 8.30 |
| CHEMBL514032 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443435 | — | EC50 | = | 0.03981 | nM | 10.40 |
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL483200 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL475389 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL520313 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL474616 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL514032 | — | EC50 | = | 10.0 | nM | 8.00 |