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Evidence Snapshot

Beta-1 adrenergic receptor

CHEMBL5471 SINGLE PROTEIN Cavia porcellus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:51Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5471
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-1 adrenergic receptor as ChEMBL target CHEMBL5471, mapped to UniProt B0FL73. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-1 adrenergic receptor
SINGLE PROTEIN · Cavia porcellus
As of 2026-09-13
ChEMBL target ID
CHEMBL5471
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
B0FL73
Beta-1 adrenergic receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Beta-1 adrenergic receptor matters

As of 2026-09-13

Beta-1 adrenergic receptor is reviewed as Beta-1 adrenergic receptor (UniProt B0FL73); the current evidence base includes 19 approved drugs, 545 compounds, and 169 assays, with lead potency reaching pChEMBL 10.4.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 19 approved drugs, 545 compounds, and 169 assays for this target. The dominant activity type is KD. CHEMBL443435 is the current potency anchor at pChEMBL 10.4.

Use CHEMBL443435 as the tractability anchor when discussing potency (pChEMBL 10.4).

Activity source · ChEMBL 36 via Core Engine
19 approved pChEMBL 10.4
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Beta-1 adrenergic receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt B0FL73, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

545
Total Compounds
169
Total Assays
19
Approved Drugs
IC50: 39.0, KI: 27.0, EC50: 48.0, KD: 339.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL443435
 10.4 EC50 —
No preferred name
CHEMBL30622
 10.0 Kd —
No preferred name
CHEMBL304344
 9.8 Kd —
No preferred name
CHEMBL1256786
 9.5 EC50 Approved
No preferred name
CHEMBL499
 9.4 Kd Approved

Approved Drugs

Structure Compound First Approval
FORMOTEROL
CHEMBL1256786
 2001
SALMETEROL
CHEMBL1263
 1994
ESMOLOL
CHEMBL768
 1986
BETAXOLOL
CHEMBL423
 1985
LABETALOL
CHEMBL429
 1984
ATENOLOL
CHEMBL24
 1981
TIMOLOL
CHEMBL499
 1978
METOPROLOL
CHEMBL13
 1978
PROPRANOLOL
CHEMBL27
 1967
EPINEPHRINE
CHEMBL679
 1965
ISOPROTERENOL
CHEMBL434
 1956
NOREPINEPHRINE
CHEMBL1437
 1950
PRACTOLOL
CHEMBL6995
 —
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Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:51Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5471