Compound Detail
CHEMBL1437
NOREPINEPHRINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1437 |
| Name | NOREPINEPHRINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | SFLSHLFXELFNJZ-QMMMGPOBSA-N |
| Therapeutic | ✓ Yes |
34
Targets
119
Activities
4
Assay Types
0
PK Parameters
20
Publications
8
Known Names
19
Indications
Molecular Properties
169.2
MW (Da)
0.09
ALogP
4
HBA
4
HBD
86.7
PSA (Ų)
0.47
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1950 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Cardiovascular Diseases Heart Diseases Hepatorenal Syndrome Hernias, Diaphragmatic, Congenital Hypotension Sepsis Shock Shock, Septic Stroke Syndrome Acute Lung Injury Brain Injuries Cognitive Dysfunction Depressive Disorder Hypotension, Orthostatic Inflammation Radiodermatitis Ischemic Stroke Obesity
ATC Classification
C01CA03
norepinephrine
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY
Activity Summary
Ki 59 meas. best 8.32
EC50 47 meas. best 8.92
IC50 10 meas. best 7.8
Kd 3 meas. best 5.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adrenergic receptor alpha-1 CHEMBL1907610 | EC50 | 8.92 | 6.125 | 1.2 | 4 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | Ki | 8.32 | 7.5978 | 4.8 | 9 |
| Beta-3 adrenergic receptor CHEMBL246 | EC50 | 8.26 | 8.23 | 5.5 | 2 |
| Unchecked CHEMBL612545 | EC50 | 8.18 | 6.4186 | 6.6 | 7 |
| Alpha-1A adrenergic receptor CHEMBL229 | EC50 | 8.04 | 7.2467 | 9.1 | 3 |
| Alpha-1D adrenergic receptor CHEMBL326 | EC50 | 7.92 | 7.92 | 12.0 | 1 |
| Adrenergic receptor alpha CHEMBL2094111 | IC50 | 7.8 | 6.55 | 16.0 | 2 |
| Alpha-1D adrenergic receptor CHEMBL326 | Ki | 7.65 | 7.65 | 22.4 | 1 |
| Beta-1 adrenergic receptor CHEMBL5471 | EC50 | 7.52 | 6.3267 | 30.0 | 3 |
| Adrenergic receptor alpha-2 CHEMBL2095158 | Ki | 7.52 | 7.52 | 30.0 | 1 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | IC50 | 7.48 | 6.8 | 33.0 | 2 |
| Adrenergic receptor beta CHEMBL2095166 | EC50 | 7.28 | 7.28 | 52.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | EC50 | 7.21 | 7.0475 | 61.7 | 4 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 7.2 | 7.2 | 63.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 7.18 | 7.18 | 66.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL266 | Ki | 7.11 | 7.11 | 78.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | EC50 | 6.96 | 6.65 | 110.0 | 8 |
| Beta-1 adrenergic receptor CHEMBL3252 | Ki | 6.9 | 5.94 | 126.0 | 6 |
| Adrenergic receptor alpha-2 CHEMBL2095158 | EC50 | 6.78 | 6.78 | 166.0 | 1 |
| Beta-2 adrenergic receptor CHEMBL5414 | EC50 | 6.67 | 5.595 | 213.0 | 2 |
| Alpha-1B adrenergic receptor CHEMBL3122 | Ki | 6.58 | 6.58 | 263.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL319 | Ki | 6.55 | 6.55 | 281.8 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | Ki | 6.41 | 5.9922 | 390.0 | 9 |
| Beta-1 adrenergic receptor CHEMBL5471 | Ki | 6.4 | 6.4 | 400.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL4892 | Ki | 6.35 | 6.35 | 446.7 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | EC50 | 6.35 | 6.15 | 446.7 | 5 |
| Alpha-2C adrenergic receptor CHEMBL4826 | Ki | 6.19 | 6.19 | 650.0 | 1 |
| Adrenergic receptor beta CHEMBL2095166 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL319 | EC50 | 5.93 | 5.93 | 1174.9 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 5.89 | 5.89 | 1300.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL229 | Ki | 5.82 | 5.315 | 1500.0 | 2 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | IC50 | 5.82 | 5.805 | 1500.0 | 2 |
| Cavia porcellus CHEMBL369 | EC50 | 5.82 | 5.82 | 1500.0 | 1 |
| Beta-3 adrenergic receptor CHEMBL4031 | EC50 | 5.8 | 4.9 | 1580.0 | 2 |
| Adrenergic receptor alpha-1 CHEMBL2094251 | Ki | 5.58 | 5.58 | 2600.0 | 1 |
| Adrenergic receptor beta CHEMBL2094118 | EC50 | 5.58 | 5.58 | 2600.0 | 1 |
| Alpha-1D adrenergic receptor CHEMBL223 | Ki | 5.48 | 5.48 | 3311.3 | 1 |
| Beta-2 adrenergic receptor CHEMBL210 | Ki | 5.48 | 4.745 | 3300.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 5.48 | 5.41 | 3310.0 | 2 |
| Beta-2 adrenergic receptor CHEMBL210 | Kd | 5.4 | 5.4 | 3980.0 | 2 |
| Beta-2 adrenergic receptor CHEMBL3754 | Ki | 5.38 | 5.38 | 4200.0 | 1 |
| Beta-2 adrenergic receptor CHEMBL2289 | Ki | 5.3 | 4.9433 | 5000.0 | 3 |
| Alpha-2A adrenergic receptor CHEMBL4075 | Ki | 5.24 | 5.24 | 5800.0 | 1 |
| Beta-2 adrenergic receptor CHEMBL3373 | Ki | 5.22 | 5.22 | 6000.0 | 2 |
| Alpha-1B adrenergic receptor CHEMBL315 | EC50 | 4.99 | 4.99 | 10232.9 | 1 |
| Alpha-1B adrenergic receptor CHEMBL232 | Ki | 4.69 | 4.69 | 20400.0 | 1 |
| D(1A) dopamine receptor CHEMBL2056 | Kd | 4.3 | 4.3 | 50000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine