Assay Detail
Binding
CHEMBL822168
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Binding of [3H]clonidine to alpha-2-adrenergic receptor of rat cerebral cortical membranes
21
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.21 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40986 | — | — | 1 | 7.89 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 2 | 7.89 |
| CHEMBL42359 | — | — | 1 | 7.85 |
| CHEMBL40317 | — | — | 1 | 7.70 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 3 | 7.70 |
| CHEMBL281232 | — | — | 1 | 7.55 |
| CHEMBL41818 | — | — | 1 | 7.40 |
| CHEMBL42280 | L-ADRENALINE | — | 1 | 7.35 |
| CHEMBL295651 | — | — | 1 | 7.28 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.24 |
| CHEMBL43711 | — | — | 1 | 7.22 |
| CHEMBL42370 | — | — | 1 | 7.17 |
| CHEMBL42216 | — | — | 1 | 7.11 |
| CHEMBL40268 | — | — | 1 | 6.92 |
| CHEMBL40796 | — | — | 1 | 6.50 |
| CHEMBL40593 | — | — | 1 | 6.44 |
| CHEMBL295072 | — | — | 1 | 6.26 |
| CHEMBL287587 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL679 | EPINEPHRINE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL40986 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL42359 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL40317 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL281232 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL41818 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL42280 | L-ADRENALINE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL295651 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL59 | DOPAMINE | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL43711 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL42370 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL42216 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL40268 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL40796 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL40593 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL295072 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL287587 | — | Ki | = | 600.0 | nM | 6.22 |