Adrenergic receptor alpha-2 · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P22086. Use UniProt P22086 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22086 as the stable identity anchor, then attach disease evidence before program review.
Alpha-2C adrenergic receptor
Review this target as Adrenergic receptor alpha-2, mapped to UniProt P22086. ChEMBL maps the protein component as Alpha-2C adrenergic receptor. Sequence length is 458 aa.
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This review treats Adrenergic receptor alpha-2 as ChEMBL target CHEMBL2093864, mapped to UniProt P22086. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Adrenergic receptor alpha-2 |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P22086 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-2C adrenergic receptor |
| UniProt Accession | P22086 |
| Component Type | Protein |
| Sequence Length | 458 aa |
Alpha-2C adrenergic receptor
Review this target as Adrenergic receptor alpha-2, mapped to UniProt P22086. ChEMBL maps the protein component as Alpha-2C adrenergic receptor. Sequence length is 458 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL778 | 10.82 | Ki | 0.015 | Approved |
| CHEMBL10332 | 9.92 | Kd | 0.1202 | Preclinical |
| CHEMBL353972 | 9.9 | Ki | 0.1259 | Clinical |
| CHEMBL556758 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL36616 | 9.62 | Ki | 0.24 | Preclinical |
| CHEMBL9763 | 9.51 | Kd | 0.309 | Preclinical |
| CHEMBL279807 | 9.45 | Ki | 0.3548 | Preclinical |
| CHEMBL10332 | 9.44 | Ki | 0.36 | Preclinical |
| CHEMBL10347 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL2 | 9.4 | Ki | 0.4 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 135 | 333 | 6.7 |
| assay format | 103 | 385 | 6.7 |
| protein format | 86 | 302 | 6.1 |
| cell membrane format | 51 | 591 | 7.0 |
| cell-based format | 7 | 3 | 7.0 |
| organism-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 52 | 165 | 7.1 |
| assay format | 40 | 90 | 6.6 |
| organism-based format | 28 | 3 | 6.6 |
| cell membrane format | 1 | 1 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 0 | — |