Compound Detail
CHEMBL1266
TETRAHYDROZOLINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1266 |
| Name | TETRAHYDROZOLINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | BYJAVTDNIXVSPW-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
20
Publications
4
Known Names
3
Indications
Molecular Properties
200.3
MW (Da)
2.11
ALogP
2
HBA
1
HBD
24.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1979 |
| Availability | Prescription |
| Chirality | Racemic |
Indications
Eye Manifestations Nasal Obstruction Dry Eye Syndromes
ATC Classification
R01AA06
tetryzoline
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
R01AB03
tetryzoline
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
S01GA02
tetryzoline
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
S01GA52
tetryzoline, combinations
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
IC50 2 meas. best 7.52
Ki 1 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adrenergic receptor alpha CHEMBL2094111 | Ki | 7.96 | 7.96 | 11.0 | 1 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha | Ki | = | 11.0 | nM | 7.96 | Displacement of [3H]clonidine from alpha-adrenergic receptor in rat brain | 42798 |
| Adrenergic receptor alpha-2 | IC50 | = | 30.0 | nM | 7.52 | Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit t... | 6142954 |
| Adrenergic receptor alpha-1 | IC50 | = | 1600.0 | nM | 5.8 | Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit t... | 6142954 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 14 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| 6264080 | 10.1021/jm00137a006 | Adrenergic receptor alpha | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| 6142954 | 10.1021/jm00370a011 | Oryctolagus cuniculus | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Acetylcholinesterase | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Estrogen receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | D(1A) dopamine receptor | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
| 42798 | 10.1021/jm00197a003 | Adrenergic receptor alpha | 1 |
| 42798 | 10.1021/jm00197a003 | Unchecked | 1 |
| 6264080 | 10.1021/jm00137a006 | No relevant target | 1 |
| 6142954 | 10.1021/jm00370a011 | Adrenergic receptor alpha-2 | 1 |
| 6142954 | 10.1021/jm00370a011 | Adrenergic receptor alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine