Assay Detail
Binding
CHEMBL3254212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]clonidine from alpha-adrenergic receptor in rat brain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Ultraviolet photoelectron spectroscopy of cyclic amidines. 1. Electronic structure of some alpha-adrenergic benzylimidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.31 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 8.72 |
| CHEMBL312448 | XYLOMETAZOLINE | 3.0 | 1 | 8.32 |
| CHEMBL761 | NAPHAZOLINE | 4.0 | 1 | 8.24 |
| CHEMBL1266 | TETRAHYDROZOLINE | 4.0 | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL312448 | XYLOMETAZOLINE | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL761 | NAPHAZOLINE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL1266 | TETRAHYDROZOLINE | Ki | = | 11.0 | nM | 7.96 |