Adrenergic receptor alpha-1 · PROTEIN FAMILY · Rattus norvegicus
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As of 2026-09-12Protein identity stays anchored to UniProt P15823. Use UniProt P15823 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P15823 as the stable identity anchor, then attach disease evidence before program review.
Alpha-1B adrenergic receptor
Review this target as Adrenergic receptor alpha-1, mapped to UniProt P15823. ChEMBL maps the protein component as Alpha-1B adrenergic receptor. Sequence length is 515 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Adrenergic receptor alpha-1 as ChEMBL target CHEMBL1907610, mapped to UniProt P15823. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Adrenergic receptor alpha-1 |
| Target Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
| UniProt | P15823 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-1B adrenergic receptor |
| UniProt Accession | P15823 |
| Component Type | Protein |
| Sequence Length | 515 aa |
Alpha-1B adrenergic receptor
Review this target as Adrenergic receptor alpha-1, mapped to UniProt P15823. ChEMBL maps the protein component as Alpha-1B adrenergic receptor. Sequence length is 515 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2 | 10.99 | Kd | 0.01023 | Approved |
| CHEMBL2397832 | 10.51 | Kd | 0.0309 | Preclinical |
| CHEMBL2397831 | 10.41 | Kd | 0.0389 | Preclinical |
| CHEMBL47792 | 10.33 | Ki | 0.047 | Preclinical |
| CHEMBL3968791 | 10.28 | Ki | 0.052 | Preclinical |
| CHEMBL2114071 | 10.17 | Ki | 0.068 | Preclinical |
| CHEMBL309150 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL2397833 | 10.1 | Kd | 0.07943 | Preclinical |
| CHEMBL118770 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL50451 | 10.1 | Ki | 0.08 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 163 | 884 | 7.1 |
| assay format | 145 | 690 | 6.6 |
| protein format | 131 | 605 | 7.2 |
| cell membrane format | 109 | 919 | 7.1 |
| cell-based format | 8 | 9 | 6.9 |
| organism-based format | 5 | 5 | 8.0 |
| subcellular format | 1 | 4 | 8.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 82 | 225 | 6.8 |
| tissue-based format | 66 | 137 | 6.9 |
| organism-based format | 10 | 1 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 10 | 6.6 |
| cell membrane format | 2 | 23 | 6.8 |
| tissue-based format | 1 | 4 | 7.2 |