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Compound Detail

CHEMBL3968791

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O=C(c1ccco1)N1CCN(c2cnn(CCCCCCCN3CCN(c4ccccc4Oc4ccccc4)CC3)c(=O)c2Cl)CC1

Basic Information

ChEMBL ID CHEMBL3968791
Phase Preclinical
Structure Type MOL
InChI Key QJBRUTIWANVEQC-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

659.2
MW (Da)
6.02
ALogP
9
HBA
0
HBD
87.3
PSA (Ų)
0.16
QED
2
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C36H43ClN6O4
MW 659.23
Aromatic Rings 4
Heavy Atoms 47
NP-Likeness -1.41

Activity Summary

Ki 1 meas. best 10.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 10.28 10.28 0.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
27484513 10.1016/j.ejmech.2016.07.061 Adrenergic receptor alpha-1 2

Data from ChEMBL 36 via Core Engine