Compound Detail
CHEMBL1215
PHENYLEPHRINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1215 |
| Name | PHENYLEPHRINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | SONNWYBIRXJNDC-VIFPVBQESA-N |
| Therapeutic | ✓ Yes |
19
Targets
34
Activities
3
Assay Types
3
PK Parameters
20
Publications
17
Known Names
20
Indications
Molecular Properties
167.2
MW (Da)
0.65
ALogP
3
HBA
3
HBD
52.5
PSA (Ų)
0.62
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1952 |
| Availability | OTC |
| Chirality | Single Enantiomer |
Indications
Cardiovascular Diseases Eye Manifestations Hemorrhoids Nasal Obstruction Common Cold Eye Diseases Fecal Incontinence Hypotension Influenza, Human Ischemic Stroke Respiratory Tract Infections Rhinitis, Allergic, Seasonal Stroke Acute Lung Injury Bronchiolitis Cognitive Dysfunction Mydriasis Shock, Septic Stress Disorders, Post-Traumatic Hypertension
ATC Classification
C01CA06
phenylephrine
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CARDIAC THERAPY
C05AX06
phenylephrine
Level 1: CARDIOVASCULAR SYSTEM
Level 2: VASOPROTECTIVES
R01AA04
phenylephrine
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
R01AB01
phenylephrine
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
R01BA03
phenylephrine
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
R01BA53
phenylephrine, combinations
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
S01FB01
phenylephrine
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
S01GA05
phenylephrine
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
S01GA55
phenylephrine, combinations
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
EC50 17 meas. best 9.07
Ki 14 meas. best 6.79
IC50 3 meas. best 7.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-1B adrenergic receptor CHEMBL232 | EC50 | 9.07 | 8.65 | 0.9 | 2 |
| Alpha-1A adrenergic receptor CHEMBL4892 | EC50 | 8.05 | 8.05 | 9.0 | 1 |
| Alpha-1B adrenergic receptor CHEMBL3988626 | EC50 | 8.0 | 8.0 | 10.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL229 | EC50 | 7.26 | 6.68 | 55.0 | 3 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | IC50 | 7.11 | 6.695 | 78.0 | 2 |
| Alpha-1D adrenergic receptor CHEMBL326 | EC50 | 6.81 | 6.81 | 154.9 | 1 |
| Alpha-1D adrenergic receptor CHEMBL326 | Ki | 6.79 | 6.79 | 162.2 | 1 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | Ki | 6.57 | 6.49 | 270.0 | 2 |
| Alpha-2A adrenergic receptor CHEMBL1867 | EC50 | 6.51 | 6.415 | 306.0 | 2 |
| Alpha-2C adrenergic receptor CHEMBL1916 | EC50 | 6.47 | 6.47 | 340.0 | 1 |
| Adrenergic receptor alpha-2 CHEMBL2095158 | Ki | 6.41 | 6.41 | 390.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL4892 | Ki | 6.03 | 6.03 | 933.2 | 1 |
| Alpha-1A adrenergic receptor CHEMBL319 | Ki | 6.01 | 6.01 | 977.2 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 5.96 | 5.96 | 1110.1 | 1 |
| Alpha-1B adrenergic receptor CHEMBL3122 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Alpha-1A adrenergic receptor CHEMBL319 | EC50 | 5.78 | 5.78 | 1659.6 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.6 | 5.405 | 2500.0 | 2 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 5.49 | 5.49 | 3216.6 | 1 |
| Cavia porcellus CHEMBL369 | EC50 | 5.22 | 4.79 | 6000.0 | 3 |
| Adrenergic receptor beta CHEMBL2094118 | EC50 | 5.22 | 5.22 | 6000.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | Ki | 5.21 | 5.21 | 6100.0 | 1 |
| Alpha-1B adrenergic receptor CHEMBL315 | EC50 | 4.96 | 4.96 | 10964.8 | 1 |
| Beta-1 adrenergic receptor CHEMBL3252 | Ki | 4.89 | 4.89 | 13000.0 | 1 |
| Adrenergic receptor beta; ADRB1 & ADRB3 CHEMBL2097169 | Ki | 4.89 | 4.89 | 13000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 30.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 17.3 | mL.min-1.g-1 | Homo sapiens |
| F | 49.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3885881 | Rattus norvegicus | 482 |
| - | 10.6019/CHEMBL4689842 | HEK-293T | 10 |
| - | 10.6019/CHEMBL4689842 | U2OS | 8 |
| 8831777 | 10.1021/jm960354u | Alpha-1A adrenergic receptor | 6 |
| 2982020 | 10.1021/jm00380a017 | Alpha-1A adrenergic receptor | 6 |
| - | 10.6019/CHEMBL5209801 | C5a anaphylatoxin chemotactic receptor 1 | 5 |
| - | 10.6019/CHEMBL5209801 | Free fatty acid receptor 4 | 5 |
| - | 10.6019/CHEMBL5209801 | Adhesion G-protein coupled receptor F1 | 5 |
| - | 10.6019/CHEMBL5209801 | Glucagon-like peptide 1 receptor | 5 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | CX3C chemokine receptor 1 | 5 |
| - | 10.6019/CHEMBL5209801 | Alpha-2A adrenergic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Apelin receptor | 5 |
| - | 10.6019/CHEMBL4689842 | Fibroblast | 5 |
| - | 10.6019/CHEMBL5209801 | Type-1 angiotensin II receptor | 5 |
| - | 10.6019/CHEMBL5209801 | N-formyl peptide receptor 2 | 5 |
| - | 10.6019/CHEMBL5209801 | Beta-2 adrenergic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Glucose-dependent insulinotropic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Sphingosine 1-phosphate receptor 1 | 5 |
| 37468498 | 10.1038/s41467-023-40064-9 | Cannabinoid receptor 1 | 4 |
Data from ChEMBL 36 via Core Engine