Assay Detail
Binding
CHEMBL648413
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Binding affinity towards Alpha-1A adrenergic receptor in rat submaxillary glands
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Submaxillary gland |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.25 | 8.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336161 | — | — | 1 | 8.65 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 8.19 |
| CHEMBL109783 | — | — | 1 | 8.05 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.55 |
| CHEMBL133451 | — | — | 1 | 6.02 |
| CHEMBL1215 | PHENYLEPHRINE | 4.0 | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336161 | — | Ki | = | 2.239 | nM | 8.65 |
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL109783 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 281.84 | nM | 6.55 |
| CHEMBL133451 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL1215 | PHENYLEPHRINE | Ki | = | 977.24 | nM | 6.01 |