Assay Detail
Binding
CHEMBL3404319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha-1A adrenergic receptor (unknown origin) after 5 hrs by CCF4-AM staining-based cellular assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.26 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1215 | PHENYLEPHRINE | 4.0 | 1 | 7.26 |
| CHEMBL3400593 | — | — | 1 | - |
| CHEMBL3400595 | — | — | 1 | - |
| CHEMBL3400596 | — | — | 1 | - |
| CHEMBL3400598 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1215 | PHENYLEPHRINE | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3400593 | — | EC50 | - | — | - | |
| CHEMBL3400595 | — | EC50 | - | — | - | |
| CHEMBL3400596 | — | EC50 | - | — | - | |
| CHEMBL3400598 | — | EC50 | - | — | - |