Assay Detail
Functional
CHEMBL5442698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
GPCR PRESTO-Tango dose-response in agonist mode with target: ADRA2A
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HTLA |
| Category | GPCR beta-arrestin recruitment assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - GPCR Dose-Respose
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.36 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2106195 | DEXMEDETOMIDINE HYDROCHLORIDE | 4.0 | 1 | 9.17 |
| CHEMBL2062257 | — | — | 1 | 8.78 |
| CHEMBL1200791 | OXYMETAZOLINE HYDROCHLORIDE | 4.0 | 1 | 8.48 |
| CHEMBL1705 | CLONIDINE HYDROCHLORIDE | 4.0 | 1 | 8.28 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 8.25 |
| CHEMBL1200494 | GUANFACINE HYDROCHLORIDE | 4.0 | 1 | 7.93 |
| CHEMBL5087452 | — | — | 1 | 7.52 |
| CHEMBL1200329 | TIZANIDINE HYDROCHLORIDE | 4.0 | 1 | 7.48 |
| CHEMBL2261346 | — | — | 1 | 6.87 |
| CHEMBL1256876 | — | — | 1 | 6.54 |
| CHEMBL1201087 | CABERGOLINE | 4.0 | 1 | 6.54 |
| CHEMBL520992 | — | — | 1 | 6.50 |
| CHEMBL1215 | PHENYLEPHRINE | 4.0 | 1 | 6.32 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | 4.0 | 1 | 5.94 |
| CHEMBL3143955 | — | — | 1 | 5.75 |
| CHEMBL505308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2106195 | DEXMEDETOMIDINE HYDROCHLORIDE | EC50 | = | 0.6747 | nM | 9.17 |
| CHEMBL2062257 | — | EC50 | = | 1.666 | nM | 8.78 |
| CHEMBL1200791 | OXYMETAZOLINE HYDROCHLORIDE | EC50 | = | 3.29 | nM | 8.48 |
| CHEMBL1705 | CLONIDINE HYDROCHLORIDE | EC50 | = | 5.259 | nM | 8.28 |
| CHEMBL679 | EPINEPHRINE | EC50 | = | 5.626 | nM | 8.25 |
| CHEMBL1200494 | GUANFACINE HYDROCHLORIDE | EC50 | = | 11.77 | nM | 7.93 |
| CHEMBL5087452 | — | EC50 | = | 30.11 | nM | 7.52 |
| CHEMBL1200329 | TIZANIDINE HYDROCHLORIDE | EC50 | = | 32.91 | nM | 7.48 |
| CHEMBL2261346 | — | EC50 | = | 134.67 | nM | 6.87 |
| CHEMBL1256876 | — | EC50 | = | 291.09 | nM | 6.54 |
| CHEMBL1201087 | CABERGOLINE | EC50 | = | 285.43 | nM | 6.54 |
| CHEMBL520992 | — | EC50 | = | 319.98 | nM | 6.50 |
| CHEMBL1215 | PHENYLEPHRINE | EC50 | = | 476.65 | nM | 6.32 |
| CHEMBL1557 | DOPAMINE HYDROCHLORIDE | EC50 | = | 1144.73 | nM | 5.94 |
| CHEMBL3143955 | — | EC50 | = | 1762.4 | nM | 5.75 |
| CHEMBL505308 | — | EC50 | > | 10000.0 | nM | - |