Alpha-1A adrenergic receptor · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P18130. Use UniProt P18130 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18130 as the stable identity anchor, then attach disease evidence before program review.
Alpha-1A adrenergic receptor
Review this target as Alpha-1A adrenergic receptor, mapped to UniProt P18130. Sequence length is 466 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha-1A adrenergic receptor as ChEMBL target CHEMBL4892, mapped to UniProt P18130. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Alpha-1A adrenergic receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P18130 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-1A adrenergic receptor |
| UniProt Accession | P18130 |
| Component Type | Protein |
| Sequence Length | 466 aa |
Alpha-1A adrenergic receptor
Review this target as Alpha-1A adrenergic receptor, mapped to UniProt P18130. Sequence length is 466 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL324090 | 10.52 | Ki | 0.03 | Clinical |
| CHEMBL1259217 | 10.17 | Ki | 0.067 | Preclinical |
| CHEMBL91278 | 10.1 | Ki | 0.07943 | Preclinical |
| CHEMBL1259113 | 10.09 | Ki | 0.082 | Preclinical |
| CHEMBL1258988 | 10.07 | Ki | 0.086 | Preclinical |
| CHEMBL1259144 | 10.06 | Ki | 0.088 | Preclinical |
| CHEMBL1259112 | 10.02 | Ki | 0.096 | Preclinical |
| CHEMBL1259145 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL2 | 9.9 | Ki | 0.1259 | Approved |
| CHEMBL836 | 9.9 | Ki | 0.1259 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 13 | 105 | 6.1 |
| single protein format | 11 | 58 | 8.1 |
| assay format | 8 | 20 | 7.5 |
| cell-based format | 4 | 62 | 9.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 5 | 6.8 |