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Evidence Snapshot

Alpha-1A adrenergic receptor

CHEMBL4892 SINGLE PROTEIN Bos taurus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T16:29:39Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4892
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Alpha-1A adrenergic receptor as ChEMBL target CHEMBL4892, mapped to UniProt P18130. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Alpha-1A adrenergic receptor
SINGLE PROTEIN · Bos taurus
As of 2026-09-13
ChEMBL target ID
CHEMBL4892
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P18130
Alpha-1A adrenergic receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Alpha-1A adrenergic receptor matters

As of 2026-09-13

Alpha-1A adrenergic receptor is reviewed as Alpha-1A adrenergic receptor (UniProt P18130); the current evidence base includes 18 approved drugs, 252 compounds, and 38 assays, with lead potency reaching pChEMBL 10.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 18 approved drugs, 252 compounds, and 38 assays for this target. The dominant activity type is KI. CHEMBL324090 is the current potency anchor at pChEMBL 10.5.

Use CHEMBL324090 as the tractability anchor when discussing potency (pChEMBL 10.5).

Activity source · ChEMBL 36 via Core Engine
18 approved pChEMBL 10.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Alpha-1A adrenergic receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P18130, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

252
Total Compounds
38
Total Assays
18
Approved Drugs
IC50: 72.0, KI: 206.0, EC50: 5.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL324090
 10.5 Ki Clinical
No preferred name
CHEMBL1259217
 10.2 Ki —
No preferred name
CHEMBL91278
 10.1 Ki —
No preferred name
CHEMBL1259113
 10.1 Ki —
No preferred name
CHEMBL1258988
 10.1 Ki —

Approved Drugs

Structure Compound First Approval
ALFUZOSIN
CHEMBL709
 2003
DEXMEDETOMIDINE
CHEMBL778
 1999
TAMSULOSIN
CHEMBL836
 1997
SERTINDOLE
CHEMBL12713
 1996
TIZANIDINE
CHEMBL1079
 1996
CLOZAPINE
CHEMBL42
 1989
TERAZOSIN
CHEMBL611
 1987
OXYMETAZOLINE
CHEMBL762
 1986
PRAZOSIN
CHEMBL2
 1976
CLONIDINE
CHEMBL134
 1974
HALOPERIDOL
CHEMBL54
 1967
PHENTOLAMINE
CHEMBL597
 1952
PHENYLEPHRINE
CHEMBL1215
 1952
NOREPINEPHRINE
CHEMBL1437
 1950
MIANSERIN
CHEMBL6437
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T16:29:39Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4892