Alpha-1B adrenergic receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P35368. Use UniProt P35368 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35368 as the stable identity anchor, then attach disease evidence before program review.
Alpha-1B adrenergic receptor
Review this target as Alpha-1B adrenergic receptor, mapped to UniProt P35368. Sequence length is 520 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha-1B adrenergic receptor as ChEMBL target CHEMBL232, mapped to UniProt P35368. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Alpha-1B adrenergic receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35368 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-1B adrenergic receptor |
| UniProt Accession | P35368 |
| Component Type | Protein |
| Sequence Length | 520 aa |
Alpha-1B adrenergic receptor
Review this target as Alpha-1B adrenergic receptor, mapped to UniProt P35368. Sequence length is 520 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2 | 10.57 | Ki | 0.027 | Approved |
| CHEMBL25554 | 10.42 | Ki | 0.038 | Preclinical |
| CHEMBL42472 | 10.4 | Ki | 0.03981 | Preclinical |
| CHEMBL342062 | 10.15 | Ki | 0.07079 | Preclinical |
| CHEMBL324090 | 10.1 | Ki | 0.08 | Clinical |
| CHEMBL5618291 | 10.07 | Ki | 0.086 | Preclinical |
| CHEMBL3582270 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL27013 | 9.96 | Ki | 0.1096 | Preclinical |
| CHEMBL836 | 9.89 | EC50 | 0.13 | Approved |
| CHEMBL4126860 | 9.89 | Ki | 0.1288 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 241 | 600 | 6.8 |
| cell-based format | 100 | 548 | 7.3 |
| tissue-based format | 10 | 133 | 7.1 |
| assay format | 5 | 77 | 6.4 |
| cell membrane format | 2 | 7 | 7.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 29 | 66 | 6.6 |
| assay format | 28 | 88 | 7.3 |
| tissue-based format | 5 | 13 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 45 | 7.2 |