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Target Snapshot

CHEMBL2094118 Target Snapshot

Adrenergic receptor beta · PROTEIN FAMILY · Homo sapiens

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741Compounds
102Assays
10Approved Drugs
404.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Adrenergic receptor beta shows approved-linked disease relevance led by congestive heart failure. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P08588. Start with congestive heart failure, then reuse UniProt P08588 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with congestive heart failure, then reuse UniProt P08588 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 3 linked drugs
Open source guide
Disease program
congestive heart failure

Adrenergic receptor beta shows approved-linked disease relevance led by congestive heart failure. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.

Start review with congestive heart failure because it currently carries approved-linked support. Linked drugs include CARVEDILOL, CARVEDILOL PHOSPHATE, ISOPROTERENOL HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 3 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Adrenergic receptor beta as ChEMBL target CHEMBL2094118, mapped to UniProt P08588. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Adrenergic receptor beta
PROTEIN FAMILY · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2094118
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P08588
Beta-1 adrenergic receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Adrenergic receptor beta is the right protein anchor across sources, using UniProt P08588 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why congestive heart failure is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameAdrenergic receptor beta
Target TypePROTEIN FAMILY
OrganismHomo sapiens
UniProtP08588
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-1 adrenergic receptor
UniProt AccessionP08588
Component TypeProtein
Sequence Length477 aa

Beta-1 adrenergic receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Adrenergic receptor beta, mapped to UniProt P08588. ChEMBL maps the protein component as Beta-1 adrenergic receptor. Sequence length is 477 aa.

Mapped IDP08588
Review nameAdrenergic receptor beta
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Adrenergic receptor beta shows approved-linked disease relevance led by congestive heart failure. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
congestive heart failure
3 linked drugs · 3 direct · 3 efficacy
Linked drugCARVEDILOL
Linked drugCARVEDILOL PHOSPHATE
Linked drugISOPROTERENOL HYDROCHLORIDE
Approved-linked Approved
hypertension
2 linked drugs · 2 direct · 2 efficacy
Linked drugCARVEDILOL
Linked drugCARVEDILOL PHOSPHATE
Approved-linked Approved
myocardial infarction
2 linked drugs · 2 direct · 2 efficacy
Linked drugCARVEDILOL
Linked drugCARVEDILOL PHOSPHATE
Approved-linked Approved
Ventricular Dysfunction, Left
2 linked drugs · 2 direct · 2 efficacy
Linked drugCARVEDILOL
Linked drugCARVEDILOL PHOSPHATE
Approved-linked Approved
cardiovascular disease
1 linked drug · 1 direct · 1 efficacy
Linked drugCARVEDILOL
Approved-linked Approved
heart failure
1 linked drug · 1 direct · 1 efficacy
Linked drugCARVEDILOL
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with congestive heart failure because it currently carries approved-linked support. Linked drugs include CARVEDILOL, CARVEDILOL PHOSPHATE, ISOPROTERENOL HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasecongestive heart failure
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

10
Approved
3
Phase II
Assay Mix

Activity Type Distribution

IC5051.0
KI7.0
EC5036.0
KD310.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL27 8.9 Kd 1.259 Approved
CHEMBL1671 8.89 Kd 1.288 Approved
CHEMBL266195 8.64 IC50 2.3 Clinical
CHEMBL6920 8.6 Kd 2.512 Preclinical
CHEMBL6935 8.5 Kd 3.162 Preclinical
CHEMBL1203105 8.46 Kd 3.467 Preclinical
CHEMBL7467 8.4 Kd 3.981 Clinical
CHEMBL7725 8.4 Kd 3.981 Preclinical
CHEMBL27 8.4 IC50 4.0 Approved
CHEMBL51667 8.37 IC50 4.3 Preclinical
Distribution

pChEMBL Value Distribution

35
5.0
38
5.5
64
6.0
72
6.5
51
7.0
23
7.5
25
8.0
7
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LABETALOL HYDROCHLORIDE
CHEMBL1200323
Approved 1984
Properties Compare Identifier
PROPRANOLOL
CHEMBL27
Approved 1967
Properties Compare Identifier
PROPRANOLOL HYDROCHLORIDE
CHEMBL1671
Approved 1967
Properties Compare Identifier
ISOPROTERENOL
CHEMBL434
Approved 1956
Properties Compare Identifier
PRACTOLOL
CHEMBL6995
Properties Compare Identifier
Assay Landscape

Assay Landscape

102
Total Assays
271
Tested Compounds
2
Assay Types
Functional — 57 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 27 9 6.0
tissue-based format 14 9 5.8
organism-based format 12 0 —
cell-based format 4 2 7.5
Binding — 45 assays, 271 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 40 201 6.4
tissue-based format 5 70 7.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine