Compound Detail
CHEMBL7467
FLESTOLOL 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL7467 |
| Name | FLESTOLOL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ZPLOQFLCMVIWRY-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
2
PK Parameters
6
Publications
1
Known Names
Molecular Properties
327.4
MW (Da)
0.38
ALogP
5
HBA
4
HBD
113.7
PSA (Ų)
0.52
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
Kd 2 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adrenergic receptor beta CHEMBL2094118 | Kd | 8.4 | 8.25 | 4.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.25 | hr | Canis lupus familiaris |
| T1/2 | 0.04167 | hr | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adrenergic receptor beta | Kd | = | 3.981 | nM | 8.4 | In vitro blocking of beta adrenergic receptor in guinea pig trachea | 6146718 |
| Adrenergic receptor beta | Kd | = | 7.943 | nM | 8.1 | In Vitro inhibition of the beta adrenergic receptor in guinea pig atria | 6146718 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 6146718 | 10.1021/jm00374a013 | Canis familiaris | 4 |
| 6146718 | 10.1021/jm00374a013 | Adrenergic receptor beta | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 6146718 | 10.1021/jm00374a013 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine