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Assay Detail

CHEMBL647671

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro blocking of beta adrenergic receptor in guinea pig trachea
ChEMBL ↗
68
Total Activities
68
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Trachea
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor beta (CHEMBL2094118) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

[(Arylcarbonyl)oxy]propanolamines. 1. Novel beta-blockers with ultrashort duration of action.
Kam ST, Matier WL, Mai KX, Barcelon-Yang C, Borgman RJ, O'Donnell JP, Stampfli HF, Sum CY, Anderson WG, Gorczynski RJ.
J Med Chem (1984) 27 : 1007 -1016
PubMed 6146718 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 67 7.04 8.90
pA2 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27 PROPRANOLOL 4.0 1 8.90
CHEMBL7725 — — 1 8.40
CHEMBL7467 FLESTOLOL 2.0 1 8.40
CHEMBL6920 — — 1 8.20
CHEMBL7195 — — 1 8.10
CHEMBL7362 — — 1 8.10
CHEMBL6795 — — 1 8.10
CHEMBL7249 — — 1 8.00
CHEMBL414207 — — 1 8.00
CHEMBL7313 — — 1 8.00
CHEMBL7024 — — 1 8.00
CHEMBL7337 — — 1 7.90
CHEMBL1201899 — — 1 7.90
CHEMBL268141 — — 1 7.80
CHEMBL266546 — — 1 7.70
CHEMBL263085 — — 1 7.70
CHEMBL267416 — — 1 7.70
CHEMBL7692 — — 1 7.60
CHEMBL6870 — — 1 7.50
CHEMBL7330 — — 1 7.50
CHEMBL7154 — — 1 7.40
CHEMBL7462 — — 1 7.40
CHEMBL7622 — — 1 7.40
CHEMBL7620 — — 1 7.30
CHEMBL6957 — — 1 7.30
CHEMBL7386 — — 1 7.30
CHEMBL6863 — — 1 7.30
CHEMBL7750 — — 1 7.20
CHEMBL7665 — — 1 7.20
CHEMBL6535 — — 1 7.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27 PROPRANOLOL Kd = 1.259 nM 8.90
CHEMBL7725 — Kd = 3.981 nM 8.40
CHEMBL7467 FLESTOLOL Kd = 3.981 nM 8.40
CHEMBL6920 — Kd = 6.31 nM 8.20
CHEMBL7195 — Kd = 7.943 nM 8.10
CHEMBL7362 — Kd = 7.943 nM 8.10
CHEMBL6795 — Kd = 7.943 nM 8.10
CHEMBL7249 — Kd = 10.0 nM 8.00
CHEMBL414207 — Kd = 10.0 nM 8.00
CHEMBL7313 — Kd = 10.0 nM 8.00
CHEMBL7024 — Kd = 10.0 nM 8.00
CHEMBL7337 — Kd = 12.59 nM 7.90
CHEMBL1201899 — Kd = 12.59 nM 7.90
CHEMBL268141 — Kd = 15.85 nM 7.80
CHEMBL267416 — Kd = 19.95 nM 7.70
CHEMBL266546 — Kd = 19.95 nM 7.70
CHEMBL263085 — Kd = 19.95 nM 7.70
CHEMBL7692 — Kd = 25.12 nM 7.60
CHEMBL6870 — Kd = 31.62 nM 7.50
CHEMBL7330 — Kd = 31.62 nM 7.50
CHEMBL7154 — Kd = 39.81 nM 7.40
CHEMBL7462 — Kd = 39.81 nM 7.40
CHEMBL7622 — Kd = 39.81 nM 7.40
CHEMBL6863 — Kd = 50.12 nM 7.30
CHEMBL7386 — Kd = 50.12 nM 7.30
CHEMBL7620 — Kd = 50.12 nM 7.30
CHEMBL6957 — Kd = 50.12 nM 7.30
CHEMBL7750 — Kd = 63.1 nM 7.20
CHEMBL7665 — Kd = 63.1 nM 7.20
CHEMBL6535 — Kd = 63.1 nM 7.20
CHEMBL7459 — Kd = 63.1 nM 7.20
CHEMBL414019 — Kd = 63.1 nM 7.20
CHEMBL6960 — Kd = 63.1 nM 7.20
CHEMBL269360 — Kd = 79.43 nM 7.10
CHEMBL266760 — Kd = 79.43 nM 7.10
CHEMBL7484 — Kd = 79.43 nM 7.10
CHEMBL6981 — Kd = 100.0 nM 7.00
CHEMBL6878 — Kd = 100.0 nM 7.00
CHEMBL7663 — Kd = 100.0 nM 7.00
CHEMBL6984 — Kd = 100.0 nM 7.00
CHEMBL6840 — Kd = 158.49 nM 6.80
CHEMBL7733 — Kd = 158.49 nM 6.80
CHEMBL266268 — Kd = 158.49 nM 6.80
CHEMBL7332 — Kd = 158.49 nM 6.80
CHEMBL268430 — Kd = 199.53 nM 6.70
CHEMBL269278 — Kd = 199.53 nM 6.70
CHEMBL7310 — Kd = 251.19 nM 6.60
CHEMBL7739 — Kd = 251.19 nM 6.60
CHEMBL264723 — Kd = 251.19 nM 6.60
CHEMBL269523 — Kd = 316.23 nM 6.50