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Assay Detail

CHEMBL647669

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In Vitro inhibition of the beta adrenergic receptor in guinea pig atria
ChEMBL ↗
91
Total Activities
91
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor beta (CHEMBL2094118) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

[(Arylcarbonyl)oxy]propanolamines. 1. Novel beta-blockers with ultrashort duration of action.
Kam ST, Matier WL, Mai KX, Barcelon-Yang C, Borgman RJ, O'Donnell JP, Stampfli HF, Sum CY, Anderson WG, Gorczynski RJ.
J Med Chem (1984) 27 : 1007 -1016
PubMed 6146718 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 89 6.71 8.70
pA2 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27 PROPRANOLOL 4.0 1 8.70
CHEMBL6920 — — 1 8.60
CHEMBL6935 — — 1 8.50
CHEMBL7467 FLESTOLOL 2.0 1 8.10
CHEMBL7154 — — 1 8.00
CHEMBL7725 — — 1 7.80
CHEMBL7330 — — 1 7.80
CHEMBL7750 — — 1 7.70
CHEMBL263085 — — 1 7.70
CHEMBL7249 — — 1 7.50
CHEMBL6795 — — 1 7.40
CHEMBL7692 — — 1 7.40
CHEMBL7233 — — 1 7.40
CHEMBL6870 — — 1 7.40
CHEMBL7337 — — 1 7.30
CHEMBL7313 — — 1 7.30
CHEMBL268141 — — 1 7.20
CHEMBL414207 — — 1 7.10
CHEMBL7663 — — 1 7.10
CHEMBL6878 — — 1 7.00
CHEMBL269278 — — 1 7.00
CHEMBL7620 — — 1 7.00
CHEMBL7487 — — 1 7.00
CHEMBL7733 — — 1 7.00
CHEMBL1201899 — — 1 7.00
CHEMBL427995 — — 1 6.90
CHEMBL266548 — — 1 6.90
CHEMBL264723 — — 1 6.90
CHEMBL7195 — — 1 6.80
CHEMBL7459 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27 PROPRANOLOL Kd = 1.995 nM 8.70
CHEMBL6920 — Kd = 2.512 nM 8.60
CHEMBL6935 — Kd = 3.162 nM 8.50
CHEMBL7467 FLESTOLOL Kd = 7.943 nM 8.10
CHEMBL7154 — Kd = 10.0 nM 8.00
CHEMBL7725 — Kd = 15.85 nM 7.80
CHEMBL7330 — Kd = 15.85 nM 7.80
CHEMBL7750 — Kd = 19.95 nM 7.70
CHEMBL263085 — Kd = 19.95 nM 7.70
CHEMBL7249 — Kd = 31.62 nM 7.50
CHEMBL6870 — Kd = 39.81 nM 7.40
CHEMBL7233 — Kd = 39.81 nM 7.40
CHEMBL7692 — Kd = 39.81 nM 7.40
CHEMBL6795 — Kd = 39.81 nM 7.40
CHEMBL7313 — Kd = 50.12 nM 7.30
CHEMBL7337 — Kd = 50.12 nM 7.30
CHEMBL268141 — Kd = 63.1 nM 7.20
CHEMBL414207 — Kd = 79.43 nM 7.10
CHEMBL7663 — Kd = 79.43 nM 7.10
CHEMBL6878 — Kd = 100.0 nM 7.00
CHEMBL269278 — Kd = 100.0 nM 7.00
CHEMBL7620 — Kd = 100.0 nM 7.00
CHEMBL7487 — Kd = 100.0 nM 7.00
CHEMBL7733 — Kd = 100.0 nM 7.00
CHEMBL1201899 — Kd = 100.0 nM 7.00
CHEMBL427995 — Kd = 125.89 nM 6.90
CHEMBL264723 — Kd = 125.89 nM 6.90
CHEMBL266548 — Kd = 125.89 nM 6.90
CHEMBL7195 — Kd = 158.49 nM 6.80
CHEMBL6840 — Kd = 158.49 nM 6.80
CHEMBL6957 — Kd = 158.49 nM 6.80
CHEMBL7024 — Kd = 158.49 nM 6.80
CHEMBL7462 — Kd = 158.49 nM 6.80
CHEMBL7332 — Kd = 158.49 nM 6.80
CHEMBL266546 — Kd = 158.49 nM 6.80
CHEMBL7533 — Kd = 158.49 nM 6.80
CHEMBL6535 — Kd = 158.49 nM 6.80
CHEMBL7622 — Kd = 158.49 nM 6.80
CHEMBL7459 — Kd = 158.49 nM 6.80
CHEMBL7310 — Kd = 199.53 nM 6.70
CHEMBL267416 — Kd = 199.53 nM 6.70
CHEMBL7665 — Kd = 199.53 nM 6.70
CHEMBL269523 — Kd = 251.19 nM 6.60
CHEMBL266760 — Kd = 251.19 nM 6.60
CHEMBL7307 — Kd = 251.19 nM 6.60
CHEMBL6863 — Kd = 251.19 nM 6.60
CHEMBL6995 PRACTOLOL Kd = 251.19 nM 6.60
CHEMBL7386 — Kd = 251.19 nM 6.60
CHEMBL7127 — Kd = 251.19 nM 6.60
CHEMBL6984 — Kd = 251.19 nM 6.60