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Compound Detail

CHEMBL427995

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CC(C)(C)NCC(O)COC(=O)c1ccc2c(c1)OCO2

Basic Information

ChEMBL ID CHEMBL427995
Phase Preclinical
Structure Type MOL
InChI Key BHKIETLWWVIVNI-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

295.3
MW (Da)
1.32
ALogP
6
HBA
2
HBD
77.0
PSA (Ų)
0.80
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H21NO5
MW 295.33
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness -0.13

Activity Summary

Kd 1 meas. best 6.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor beta
CHEMBL2094118
Kd 6.9 6.9 125.9 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Adrenergic receptor beta Kd = 125.89 nM 6.9 In Vitro inhibition of the beta adrenergic receptor in guinea pig atria 6146718

Literature References

PubMed DOI Target Context # Activities
6146718 10.1021/jm00374a013 Adrenergic receptor beta 1
6146718 10.1021/jm00374a013 Canis familiaris 1

Data from ChEMBL 36 via Core Engine