Assay Detail
Binding
CHEMBL859457
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Binding affinity towards hamster clonal Alpha-1B adrenergic receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Alpha-1B adrenergic receptor (CHEMBL3122) ↗| Type | SINGLE PROTEIN |
| Organism | Mesocricetus auratus |
Publication
Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.86 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 6.69 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.58 |
| CHEMBL1215 | PHENYLEPHRINE | 4.0 | 1 | 5.90 |
| CHEMBL109783 | — | — | 1 | 5.68 |
| CHEMBL336161 | — | — | 1 | 5.55 |
| CHEMBL133451 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL1215 | PHENYLEPHRINE | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL109783 | — | Ki | = | 2089.3 | nM | 5.68 |
| CHEMBL336161 | — | Ki | = | 2818.38 | nM | 5.55 |
| CHEMBL133451 | — | Ki | = | 17378.01 | nM | 4.76 |