Alpha-2C adrenergic receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Alpha-2C adrenergic receptor shows clinical signal disease relevance led by Alzheimer disease. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P18825. Start with Alzheimer disease, then reuse UniProt P18825 as the stable protein anchor across project notes and exports.
Start with Alzheimer disease, then reuse UniProt P18825 as the stable protein anchor across project notes and exports.
Alpha-2C adrenergic receptor shows clinical signal disease relevance led by Alzheimer disease. 1 linked drug remains visible in the same block.
Start review with Alzheimer disease because it currently carries clinical signal support. Linked drugs include ORM-12741. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAlpha-2C adrenergic receptor
Review this target as Alpha-2C adrenergic receptor, mapped to UniProt P18825. Sequence length is 462 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha-2C adrenergic receptor as ChEMBL target CHEMBL1916, mapped to UniProt P18825. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Alpha-2C adrenergic receptor is the right protein anchor across sources, using UniProt P18825 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Alzheimer disease is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Alpha-2C adrenergic receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P18825 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-2C adrenergic receptor |
| UniProt Accession | P18825 |
| Component Type | Protein |
| Sequence Length | 462 aa |
Alpha-2C adrenergic receptor
Review this target as Alpha-2C adrenergic receptor, mapped to UniProt P18825. Sequence length is 462 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Alpha-2C adrenergic receptor shows clinical signal disease relevance led by Alzheimer disease.
Start review with Alzheimer disease because it currently carries clinical signal support. Linked drugs include ORM-12741. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL435352 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL4878875 | 10.07 | IC50 | 0.085 | Preclinical |
| CHEMBL2112985 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL176261 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL180470 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL91157 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL390718 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL1256414 | 9.89 | Ki | 0.1288 | Preclinical |
| CHEMBL1255723 | 9.77 | Ki | 0.1698 | Preclinical |
| CHEMBL419316 | 9.7 | Ki | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 219 | 374 | 6.8 |
| cell-based format | 77 | 320 | 7.2 |
| cell membrane format | 2 | 79 | 6.5 |
| assay format | 1 | 11 | 6.0 |
| organism-based format | 1 | 8 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 49 | 127 | 7.0 |
| assay format | 19 | 54 | 8.3 |
| cell membrane format | 1 | 1 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 5 | 6.2 |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 5.2 |