Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL180470

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(O)cc4OC[C@H]32)CC1

Basic Information

ChEMBL ID CHEMBL180470
Phase Preclinical
Structure Type MOL
InChI Key UCFVOQSSWZQWNE-ZCIIVOIYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

419.5
MW (Da)
3.22
ALogP
6
HBA
1
HBD
57.5
PSA (Ų)
0.81
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H29N3O3
MW 419.53
Aromatic Rings 2
Heavy Atoms 31

Activity Summary

Ki 3 meas. best 10.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-2C adrenergic receptor
CHEMBL1916
Ki 10.0 10.0 0.1 1
Alpha-2A adrenergic receptor
CHEMBL1867
Ki 9.7 9.7 0.2 1
Sodium-dependent serotonin transporter
CHEMBL228
Ki 8.44 8.44 3.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15771448 10.1021/jm049619s Sodium-dependent serotonin transporter 2
15771448 10.1021/jm049619s Alpha-2A adrenergic receptor 1
15771448 10.1021/jm049619s Alpha-2C adrenergic receptor 1
15771448 10.1021/jm049619s Adrenergic receptor alpha-2 1

Data from ChEMBL 36 via Core Engine