Sodium-dependent serotonin transporter · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-12Sodium-dependent serotonin transporter shows approved-linked disease relevance led by major depressive disorder. 5 more disease programs remain visible in the same review block. 19 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P31645. Start with major depressive disorder, then reuse UniProt P31645 as the stable protein anchor across project notes and exports.
Start with major depressive disorder, then reuse UniProt P31645 as the stable protein anchor across project notes and exports.
Sodium-dependent serotonin transporter shows approved-linked disease relevance led by major depressive disorder. 5 more disease programs remain visible in the same review block. 19 linked drugs remain visible in the same block.
Start review with major depressive disorder because it currently carries approved-linked support. Linked drugs include CITALOPRAM HYDROBROMIDE, DESVENLAFAXINE, DESVENLAFAXINE FUMARATE, DESVENLAFAXINE SUCCINATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySodium-dependent serotonin transporter
Review this target as Sodium-dependent serotonin transporter, mapped to UniProt P31645. Sequence length is 630 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium-dependent serotonin transporter as ChEMBL target CHEMBL228, mapped to UniProt P31645. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Sodium-dependent serotonin transporter is the right protein anchor across sources, using UniProt P31645 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why major depressive disorder is currently framed as approved-linked support. It currently carries 19 linked drugs in the same disease frame.
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| Preferred Name | Sodium-dependent serotonin transporter |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P31645 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sodium-dependent serotonin transporter |
| UniProt Accession | P31645 |
| Component Type | Protein |
| Sequence Length | 630 aa |
Sodium-dependent serotonin transporter
Review this target as Sodium-dependent serotonin transporter, mapped to UniProt P31645. Sequence length is 630 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Sodium-dependent serotonin transporter shows approved-linked disease relevance led by major depressive disorder. 5 more disease programs remain visible in the same review block.
Start review with major depressive disorder because it currently carries approved-linked support. Linked drugs include CITALOPRAM HYDROBROMIDE, DESVENLAFAXINE, DESVENLAFAXINE FUMARATE, DESVENLAFAXINE SUCCINATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL23034 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL361259 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL2314218 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL239079 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL2314217 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL428706 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL490 | 10.4 | Ki | 0.04 | Approved |
| CHEMBL14531 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL415 | 10.33 | Ki | 0.047 | Approved |
| CHEMBL174088 | 10.3 | Ki | 0.05 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 494 | 1,562 | 7.3 |
| cell-based format | 387 | 3,301 | 7.0 |
| assay format | 20 | 403 | 7.2 |
| cell membrane format | 16 | 193 | 7.0 |
| tissue-based format | 14 | 92 | 6.6 |
| cell-free format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 83 | 6.3 |
| assay format | 7 | 39 | 7.7 |
| organism-based format | 2 | 9 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 9 | 5.9 |
| single protein format | 3 | 1 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 2 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 5.0 |