Review anchor
Sodium-dependent serotonin transporter
SINGLE PROTEIN · Homo sapiens
As of 2026-09-12
Evidence Snapshot
Sodium-dependent serotonin transporter
CHEMBL228
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium-dependent serotonin transporter as ChEMBL target CHEMBL228, mapped to UniProt P31645. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL228
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-12
www.ebi.ac.uk
UniProt accession
P31645
Sodium-dependent serotonin transporter
UniProt accession via ChEMBL component mapping
As of 2026-09-12
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-12
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Sodium-dependent serotonin transporter matters
Sodium-dependent serotonin transporter is reviewed as Sodium-dependent serotonin transporter (UniProt P31645); Sodium-dependent serotonin transporter shows approved-linked disease relevance led by major depressive disorder. 5 more disease programs remain visible in the same review block.; 19 linked drugs keep this evidence frame grounded.; the current evidence base includes 211 approved drugs, 9558 compounds, and 961 assays, with lead potency reaching pChEMBL 11.0.
Protein context
Sodium-dependent serotonin transporter
Sodium-dependent serotonin transporter Sequence length is 630 aa.
Review this target as Sodium-dependent serotonin transporter, mapped to UniProt P31645. Sequence length is 630 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P31645
Protein
Disease context
major depressive disorder
Sodium-dependent serotonin transporter shows approved-linked disease relevance led by major depressive disorder. 5 more disease programs remain visible in the same review block. 19 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include CITALOPRAM HYDROBROMIDE, DESVENLAFAXINE, DESVENLAFAXINE FUMARATE.
Start review with major depressive disorder because it currently carries approved-linked support. Linked drugs include CITALOPRAM HYDROBROMIDE, DESVENLAFAXINE, DESVENLAFAXINE FUMARATE, DESVENLAFAXINE SUCCINATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target record
Approved-linked
19 linked drugs
Activity base
Portfolio and assay base
ChEMBL currently tracks 211 approved drugs, 9558 compounds, and 961 assays for this target. The dominant activity type is IC50. CHEMBL23034 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL23034 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
211 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Sodium-dependent serotonin transporter matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P31645, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need to see why major depressive disorder is currently treated as approved-linked support.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
9558
Total Compounds
961
Total Assays
211
Approved Drugs
IC50: 5025.0, KI: 4637.0, EC50: 162.0, KD: 23.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL23034
|
11.0 | Ki | — |
|
|
No preferred name
CHEMBL361259
|
11.0 | Ki | — |
|
|
No preferred name
CHEMBL2314218
|
10.9 | Ki | — |
|
|
No preferred name
CHEMBL239079
|
10.5 | Ki | — |
|
|
No preferred name
CHEMBL2314217
|
10.5 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
LUMATEPERONE
CHEMBL3306803
|
2019 |
|
|
LUMATEPERONE TOSYLATE
CHEMBL3233142
|
2019 |
|
|
COCAINE HYDROCHLORIDE
CHEMBL529437
|
2017 |
|
|
COCAINE
CHEMBL370805
|
2017 |
|
|
BREXPIPRAZOLE
CHEMBL2105760
|
2015 |
|
|
LEVOMILNACIPRAN
CHEMBL99946
|
2013 |
|
|
VORTIOXETINE
CHEMBL2104993
|
2013 |
|
|
VILAZODONE HYDROCHLORIDE
CHEMBL1615374
|
2011 |
|
|
VILAZODONE
CHEMBL439849
|
2011 |
|
|
INDACATEROL
CHEMBL1095777
|
2009 |
|
|
MILNACIPRAN
CHEMBL259209
|
2009 |
|
|
DESVENLAFAXINE
CHEMBL1118
|
2008 |
|
|
DULOXETINE
CHEMBL1175
|
2004 |
|
|
CINACALCET HYDROCHLORIDE
CHEMBL1200776
|
2004 |
|
|
ATOMOXETINE
CHEMBL641
|
2002 |
|
|
ARIPIPRAZOLE
CHEMBL1112
|
2002 |
|
|
ESCITALOPRAM
CHEMBL1508
|
2002 |
|
|
ESCITALOPRAM OXALATE
CHEMBL1200322
|
2002 |
|
|
ZIPRASIDONE
CHEMBL708
|
2001 |
|
|
IMATINIB
CHEMBL941
|
2001 |
|
|
DESLORATADINE
CHEMBL1172
|
2001 |
|
|
CITALOPRAM
CHEMBL549
|
1998 |
|
|
CITALOPRAM HYDROBROMIDE
CHEMBL1200781
|
1998 |
|
|
REBOXETINE
CHEMBL14370
|
1997 |
|
|
CLOPIDOGREL
CHEMBL1771
|
1997 |
|
|
OLANZAPINE
CHEMBL715
|
1996 |
|
|
BUTENAFINE
CHEMBL990
|
1996 |
|
|
TRAMADOL
CHEMBL1237044
|
1995 |
|
|
CARVEDILOL
CHEMBL723
|
1995 |
|
|
NEFAZODONE HYDROCHLORIDE
CHEMBL1200492
|
1994 |
|
|
NEFAZODONE
CHEMBL623
|
1994 |
|
|
FLUVOXAMINE
CHEMBL814
|
1994 |
|
|
SALMETEROL
CHEMBL1263
|
1994 |
|
|
VENLAFAXINE HYDROCHLORIDE
CHEMBL1201066
|
1993 |
|
|
CISAPRIDE
CHEMBL1729
|
1993 |
|
|
VENLAFAXINE
CHEMBL637
|
1993 |
|
|
RISPERIDONE
CHEMBL85
|
1993 |
|
|
PAROXETINE
CHEMBL490
|
1992 |
|
|
SERTRALINE
CHEMBL809
|
1991 |
|
|
EBASTINE
CHEMBL305660
|
1990 |
|
|
CLOZAPINE
CHEMBL42
|
1989 |
|
|
CLOMIPRAMINE
CHEMBL415
|
1989 |
|
|
OXICONAZOLE
CHEMBL1262
|
1988 |
|
|
ASTEMIZOLE
CHEMBL296419
|
1988 |
|
|
FLUOXETINE
CHEMBL41
|
1987 |
|
|
FLUOXETINE HYDROCHLORIDE
CHEMBL1201082
|
1987 |
|
|
SULCONAZOLE
CHEMBL1221
|
1985 |
|
|
NOMIFENSINE
CHEMBL273575
|
1984 |
|
|
ECONAZOLE
CHEMBL808
|
1982 |
|
|
ETHINYL ESTRADIOL
CHEMBL691
|
1982 |
Source Header