Assay Detail
Functional
CHEMBL839936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for serotonin transporter
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.86 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112984 | — | — | 1 | 9.30 |
| CHEMBL2112972 | — | — | 1 | 8.85 |
| CHEMBL2112976 | — | — | 1 | 8.82 |
| CHEMBL2112975 | — | — | 1 | 8.59 |
| CHEMBL176261 | — | — | 1 | 8.46 |
| CHEMBL180470 | — | — | 1 | 8.44 |
| CHEMBL435352 | — | — | 1 | 8.35 |
| CHEMBL175853 | — | — | 1 | 8.24 |
| CHEMBL2112982 | — | — | 1 | 8.14 |
| CHEMBL176116 | — | — | 1 | 8.11 |
| CHEMBL328114 | — | — | 1 | 8.08 |
| CHEMBL2112985 | — | — | 1 | 8.05 |
| CHEMBL2112983 | — | — | 1 | 8.01 |
| CHEMBL178588 | — | — | 1 | 7.92 |
| CHEMBL425324 | — | — | 1 | 7.89 |
| CHEMBL2112971 | — | — | 1 | 7.82 |
| CHEMBL2112978 | — | — | 1 | 7.80 |
| CHEMBL2112970 | — | — | 1 | 7.80 |
| CHEMBL179237 | — | — | 1 | 7.77 |
| CHEMBL2112980 | — | — | 1 | 7.66 |
| CHEMBL2112973 | — | — | 1 | 7.64 |
| CHEMBL175911 | — | — | 1 | 7.58 |
| CHEMBL180322 | — | — | 1 | 7.39 |
| CHEMBL369378 | — | — | 1 | 7.25 |
| CHEMBL426959 | — | — | 1 | 7.21 |
| CHEMBL2112981 | — | — | 1 | 7.08 |
| CHEMBL2112977 | — | — | 1 | 6.98 |
| CHEMBL2112979 | — | — | 1 | 6.97 |
| CHEMBL2112974 | — | — | 1 | 6.82 |
| CHEMBL2112969 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112984 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2112972 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL2112976 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL2112975 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL176261 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL180470 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL435352 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL175853 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL2112982 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL176116 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL328114 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL2112985 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL2112983 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL178588 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL425324 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2112971 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2112978 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2112970 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL179237 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2112980 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL2112973 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL175911 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL180322 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL369378 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL426959 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL2112981 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL2112977 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL2112979 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL2112974 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL2112969 | — | Ki | = | 154.0 | nM | 6.81 |