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Compound Detail

CHEMBL2112984

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c1ccc2c(c1)NC[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1

Basic Information

ChEMBL ID CHEMBL2112984
Phase Preclinical
Structure Type MOL
InChI Key WUSIUKLVFNJEHL-ZCYQVOJMSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

412.5
MW (Da)
3.80
ALogP
5
HBA
1
HBD
40.1
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H28N4O
MW 412.54
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -0.55

Activity Summary

Ki 3 meas. best 9.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sodium-dependent serotonin transporter
CHEMBL228
Ki 9.3 9.3 0.5 1
Alpha-2A adrenergic receptor
CHEMBL1867
Ki 8.4 8.4 4.0 1
Alpha-2C adrenergic receptor
CHEMBL1916
Ki 8.02 8.02 9.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15771448 10.1021/jm049619s Sodium-dependent serotonin transporter 2
15771448 10.1021/jm049619s Alpha-2A adrenergic receptor 1
15771448 10.1021/jm049619s Alpha-2C adrenergic receptor 1
15771448 10.1021/jm049619s Adrenergic receptor alpha-2 1

Data from ChEMBL 36 via Core Engine