Compound Detail
CHEMBL862
GUANFACINE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL862 |
| Name | GUANFACINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | INJOMKTZOLKMBF-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
11
Targets
23
Activities
3
Assay Types
9
PK Parameters
20
Publications
4
Known Names
17
Indications
Molecular Properties
246.1
MW (Da)
1.55
ALogP
2
HBA
3
HBD
79.0
PSA (Ų)
0.55
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1986 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Hypertension Alzheimer Disease Delirium Tourette Syndrome Alcohol Drinking Alcoholism Attention Deficit Disorder with Hyperactivity Cocaine-Related Disorders Depressive Disorder Marijuana Abuse Schizotypal Personality Disorder Smoking Cessation Stroke Substance-Related Disorders Tobacco Use Disorder Trigeminal Neuralgia Stress Disorders, Post-Traumatic
ATC Classification
C02AC02
guanfacine
Level 1: CARDIOVASCULAR SYSTEM
Level 2: ANTIHYPERTENSIVES
Activity Summary
Ki 12 meas. best 7.72
IC50 8 meas. best 7.35
EC50 3 meas. best 7.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nischarin CHEMBL3923 | Ki | 7.72 | 7.72 | 19.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 7.52 | 7.52 | 30.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.35 | 7.35 | 45.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 7.3 | 7.3 | 50.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | EC50 | 7.28 | 7.28 | 52.5 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 6.94 | 6.94 | 114.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | IC50 | 6.87 | 6.87 | 134.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | IC50 | 6.6 | 6.6 | 249.0 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | EC50 | 6.54 | 6.54 | 288.4 | 1 |
| Alpha-1A adrenergic receptor CHEMBL319 | Ki | 6.26 | 6.26 | 546.0 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | EC50 | 6.22 | 6.22 | 602.6 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 6.12 | 6.12 | 761.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 6.07 | 6.07 | 861.0 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 6.03 | 6.03 | 937.0 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | Ki | 5.88 | 5.88 | 1335.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL319 | IC50 | 5.87 | 5.87 | 1348.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | IC50 | 5.84 | 5.84 | 1453.0 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | IC50 | 5.68 | 5.68 | 2098.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | IC50 | 5.52 | 5.52 | 3014.0 | 1 |
| Alpha-1A adrenergic receptor CHEMBL229 | Ki | 5.33 | 5.33 | 4677.4 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | IC50 | 5.19 | 5.19 | 6447.0 | 1 |
| Alpha-1D adrenergic receptor CHEMBL223 | Ki | 4.93 | 4.93 | 11749.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 5.9 | mL.min-1.kg-1 | Homo sapiens |
| CL | 2.9 | mL.min-1.kg-1 | Homo sapiens |
| CL | 5.9 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.5 | mL.min-1.kg-1 | Homo sapiens |
| CL | 137.6 | mL.min-1.g-1 | Homo sapiens |
| Fu | 0.28 | - | Homo sapiens |
| Fu | 0.28 | - | Homo sapiens |
| MRT | 22.0 | hr | Homo sapiens |
| T1/2 | 15.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine