Assay Detail
Binding
CHEMBL1909104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.40 | 9.36 |
| Ki | 871 | 6.60 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19215 | METERGOLINE | 2.0 | 2 | 9.55 |
| CHEMBL1065 | METHYSERGIDE | 4.0 | 2 | 9.45 |
| CHEMBL1201356 | METHYLERGONOVINE | 4.0 | 2 | 9.02 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 8.66 |
| CHEMBL119443 | ERGONOVINE | 3.0 | 2 | 8.58 |
| CHEMBL157138 | LISURIDE | 3.0 | 2 | 8.49 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | — | 2 | 8.38 |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 2 | 8.36 |
| CHEMBL6437 | MIANSERIN | 4.0 | 2 | 8.33 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 2 | 8.28 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 2 | 8.22 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 2 | 8.18 |
| CHEMBL1385840 | ERGOCORNINE | — | 2 | 8.16 |
| CHEMBL42 | CLOZAPINE | 4.0 | 2 | 8.14 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 8.13 |
| CHEMBL1403281 | ERGOCRYPTINE | — | 2 | 8.09 |
| CHEMBL723 | CARVEDILOL | 4.0 | 2 | 7.82 |
| CHEMBL85 | RISPERIDONE | 4.0 | 2 | 7.82 |
| CHEMBL1909065 | MADURAMICIN ACID | 2.0 | 2 | 7.68 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 2 | 7.64 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 7.60 |
| CHEMBL1172 | DESLORATADINE | 4.0 | 2 | 7.55 |
| CHEMBL534 | KETOTIFEN | 4.0 | 2 | 7.54 |
| CHEMBL17157 | TERFENADINE | 4.0 | 2 | 7.52 |
| CHEMBL1909072 | PIPAMAZINE | 4.0 | 2 | 7.51 |
| CHEMBL715 | OLANZAPINE | 4.0 | 2 | 7.44 |
| CHEMBL577294 | 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN | 3.0 | 2 | 7.40 |
| CHEMBL643 | PROMETHAZINE | 4.0 | 2 | 7.37 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 2 | 7.35 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 2 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19215 | METERGOLINE | Ki | = | 0.281 | nM | 9.55 |
| CHEMBL1065 | METHYSERGIDE | Ki | = | 0.358 | nM | 9.45 |
| CHEMBL19215 | METERGOLINE | IC50 | = | 0.442 | nM | 9.36 |
| CHEMBL1065 | METHYSERGIDE | IC50 | = | 0.563 | nM | 9.25 |
| CHEMBL1201356 | METHYLERGONOVINE | Ki | = | 0.958 | nM | 9.02 |
| CHEMBL1201356 | METHYLERGONOVINE | IC50 | = | 1.505 | nM | 8.82 |
| CHEMBL442 | ERGOTAMINE | Ki | = | 2.203 | nM | 8.66 |
| CHEMBL119443 | ERGONOVINE | Ki | = | 2.634 | nM | 8.58 |
| CHEMBL157138 | LISURIDE | Ki | = | 3.242 | nM | 8.49 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 3.461 | nM | 8.46 |
| CHEMBL119443 | ERGONOVINE | IC50 | = | 4.139 | nM | 8.38 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | Ki | = | 4.201 | nM | 8.38 |
| CHEMBL1732 | DIHYDROERGOTAMINE | Ki | = | 4.33 | nM | 8.36 |
| CHEMBL6437 | MIANSERIN | Ki | = | 4.642 | nM | 8.33 |
| CHEMBL157138 | LISURIDE | IC50 | = | 5.095 | nM | 8.29 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 5.292 | nM | 8.28 |
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 6.008 | nM | 8.22 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | IC50 | = | 6.601 | nM | 8.18 |
| CHEMBL1113 | AMOXAPINE | Ki | = | 6.569 | nM | 8.18 |
| CHEMBL1732 | DIHYDROERGOTAMINE | IC50 | = | 6.804 | nM | 8.17 |
| CHEMBL1385840 | ERGOCORNINE | Ki | = | 6.855 | nM | 8.16 |
| CHEMBL42 | CLOZAPINE | Ki | = | 7.18 | nM | 8.14 |
| CHEMBL6437 | MIANSERIN | IC50 | = | 7.295 | nM | 8.14 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 7.487 | nM | 8.13 |
| CHEMBL1403281 | ERGOCRYPTINE | Ki | = | 8.217 | nM | 8.09 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 8.316 | nM | 8.08 |
| CHEMBL516 | CYPROHEPTADINE | IC50 | = | 9.441 | nM | 8.03 |
| CHEMBL1113 | AMOXAPINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1385840 | ERGOCORNINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1403281 | ERGOCRYPTINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL85 | RISPERIDONE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL723 | CARVEDILOL | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1909065 | MADURAMICIN ACID | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL723 | CARVEDILOL | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1626 | CLEMASTINE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1172 | DESLORATADINE | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL534 | KETOTIFEN | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL17157 | TERFENADINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1909072 | PIPAMAZINE | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1909065 | MADURAMICIN ACID | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1626 | CLEMASTINE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL715 | OLANZAPINE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL577294 | 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL643 | PROMETHAZINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL1172 | DESLORATADINE | IC50 | = | 43.0 | nM | 7.37 |