5-hydroxytryptamine receptor 2B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-145-hydroxytryptamine receptor 2B shows approved-linked disease relevance led by hemorrhage. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P41595. Start with hemorrhage, then reuse UniProt P41595 as the stable protein anchor across project notes and exports.
Start with hemorrhage, then reuse UniProt P41595 as the stable protein anchor across project notes and exports.
5-hydroxytryptamine receptor 2B shows approved-linked disease relevance led by hemorrhage. 1 linked drug remains visible in the same block.
Start review with hemorrhage because it currently carries approved-linked support. Linked drugs include METHYLERGONOVINE MALEATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxy5-hydroxytryptamine receptor 2B
Review this target as 5-hydroxytryptamine receptor 2B, mapped to UniProt P41595. Sequence length is 481 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 2B as ChEMBL target CHEMBL1833, mapped to UniProt P41595. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether 5-hydroxytryptamine receptor 2B is the right protein anchor across sources, using UniProt P41595 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hemorrhage is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | 5-hydroxytryptamine receptor 2B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P41595 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 2B |
| UniProt Accession | P41595 |
| Component Type | Protein |
| Sequence Length | 481 aa |
5-hydroxytryptamine receptor 2B
Review this target as 5-hydroxytryptamine receptor 2B, mapped to UniProt P41595. Sequence length is 481 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
5-hydroxytryptamine receptor 2B shows approved-linked disease relevance led by hemorrhage.
Start review with hemorrhage because it currently carries approved-linked support. Linked drugs include METHYLERGONOVINE MALEATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL39 | 10.15 | EC50 | 0.07079 | Clinical |
| CHEMBL3310115 | 9.96 | Ki | 0.11 | Preclinical |
| CHEMBL2028019 | 9.82 | Ki | 0.151 | Approved |
| CHEMBL149024 | 9.72 | Ki | 0.19 | Preclinical |
| CHEMBL5095172 | 9.72 | Ki | 0.19 | Clinical |
| CHEMBL473185 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL95121 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL3187365 | 9.68 | Ki | 0.21 | Approved |
| CHEMBL5081637 | 9.61 | IC50 | 0.245 | Preclinical |
| CHEMBL19215 | 9.55 | Ki | 0.281 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 498 | 645 | 6.8 |
| cell-based format | 165 | 762 | 6.9 |
| assay format | 8 | 68 | 7.1 |
| cell membrane format | 8 | 153 | 6.7 |
| organism-based format | 1 | 54 | 7.2 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 149 | 488 | 6.8 |
| assay format | 65 | 52 | 6.6 |
| single protein format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 42 | 98 | 6.9 |
| single protein format | 6 | 49 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 10 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 6.2 |