Alpha-2B adrenergic receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P18089. Use UniProt P18089 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18089 as the stable identity anchor, then attach disease evidence before program review.
Alpha-2B adrenergic receptor
Review this target as Alpha-2B adrenergic receptor, mapped to UniProt P18089. Sequence length is 450 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha-2B adrenergic receptor as ChEMBL target CHEMBL1942, mapped to UniProt P18089. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Alpha-2B adrenergic receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P18089 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-2B adrenergic receptor |
| UniProt Accession | P18089 |
| Component Type | Protein |
| Sequence Length | 450 aa |
Alpha-2B adrenergic receptor
Review this target as Alpha-2B adrenergic receptor, mapped to UniProt P18089. Sequence length is 450 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1256414 | 9.96 | Ki | 0.1096 | Preclinical |
| CHEMBL1255723 | 9.74 | Ki | 0.182 | Preclinical |
| CHEMBL1256378 | 9.69 | Ki | 0.2042 | Preclinical |
| CHEMBL157138 | 9.62 | Ki | 0.237 | Clinical |
| CHEMBL5517941 | 9.6 | Ki | 0.2512 | Preclinical |
| CHEMBL1255724 | 9.46 | Ki | 0.3467 | Preclinical |
| CHEMBL196 | 9.3 | EC50 | 0.5 | Approved |
| CHEMBL157138 | 9.29 | IC50 | 0.518 | Clinical |
| CHEMBL1256609 | 9.16 | Ki | 0.6918 | Preclinical |
| CHEMBL1909072 | 9.11 | Ki | 0.786 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 187 | 250 | 6.3 |
| cell-based format | 70 | 277 | 6.7 |
| cell membrane format | 2 | 104 | 6.5 |
| assay format | 1 | 1 | 8.1 |
| organism-based format | 1 | 8 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 36 | 107 | 6.4 |
| assay format | 20 | 15 | 7.1 |
| cell membrane format | 1 | 1 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 2 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 5.6 |