Compound Detail
CHEMBL301265
PRAMIPEXOLE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL301265 |
| Name | PRAMIPEXOLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | FASDKYOPVNHBLU-ZETCQYMHSA-N |
| Therapeutic | ✓ Yes |
20
Targets
99
Activities
4
Assay Types
1
PK Parameters
20
Publications
9
Known Names
18
Indications
Molecular Properties
211.3
MW (Da)
1.58
ALogP
4
HBA
2
HBD
50.9
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1997 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Parkinson Disease Depressive Disorder Essential Tremor Feeding and Eating Disorders Psychotic Disorders Restless Legs Syndrome Schizophrenia Tourette Syndrome Alzheimer Disease Bipolar Disorder Depressive Disorder, Major Fibromyalgia Obsessive-Compulsive Disorder Amyotrophic Lateral Sclerosis Cocaine-Related Disorders Renal Colic Substance-Related Disorders Chronic Pain
ATC Classification
N04BC05
pramipexole
Level 1: NERVOUS SYSTEM
Level 2: ANTI-PARKINSON DRUGS
Activity Summary
Ki 60 meas. best 9.35
EC50 27 meas. best 9.68
Kd 7 meas. best 10.83
IC50 5 meas. best 8.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL217 | Kd | 10.83 | 10.83 | 0.0 | 2 |
| D(3) dopamine receptor CHEMBL234 | Kd | 10.59 | 10.59 | 0.0 | 1 |
| D(3) dopamine receptor CHEMBL3138 | EC50 | 9.68 | 9.68 | 0.2 | 1 |
| D(3) dopamine receptor CHEMBL3138 | Ki | 9.35 | 9.19 | 0.5 | 3 |
| D(4) dopamine receptor CHEMBL219 | Ki | 9.31 | 7.898 | 0.5 | 10 |
| D(3) dopamine receptor CHEMBL234 | Ki | 9.18 | 8.5229 | 0.7 | 17 |
| D(3) dopamine receptor CHEMBL234 | EC50 | 9.09 | 8.7443 | 0.8 | 7 |
| D(2) dopamine receptor CHEMBL3998 | Kd | 8.8 | 8.8 | 1.6 | 1 |
| D(2) dopamine receptor CHEMBL339 | EC50 | 8.77 | 8.06 | 1.7 | 6 |
| Dopamine receptor D2 and D3 CHEMBL2111342 | EC50 | 8.7 | 8.7 | 2.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 8.51 | 8.51 | 3.1 | 1 |
| D(2) dopamine receptor CHEMBL339 | Ki | 8.51 | 7.96 | 3.1 | 2 |
| Histamine H1 receptor CHEMBL231 | Kd | 8.35 | 8.35 | 4.5 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 8.33 | 6.9188 | 4.7 | 17 |
| D(2) dopamine receptor CHEMBL217 | EC50 | 8.3 | 7.675 | 5.0 | 8 |
| D(3) dopamine receptor CHEMBL3138 | IC50 | 8.11 | 8.11 | 7.8 | 1 |
| Histamine H2 receptor CHEMBL1941 | Kd | 7.91 | 7.91 | 12.2 | 1 |
| D(4) dopamine receptor CHEMBL219 | EC50 | 7.82 | 7.82 | 15.0 | 2 |
| Histamine H4 receptor CHEMBL3759 | Kd | 7.8 | 7.8 | 16.0 | 1 |
| Dopamine receptor D2 and D3 CHEMBL2111342 | IC50 | 7.77 | 7.325 | 17.1 | 2 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 7.28 | 7.28 | 52.2 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 7.17 | 7.17 | 67.7 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 7.12 | 7.12 | 75.7 | 1 |
| Histamine H2 receptor CHEMBL1941 | EC50 | 6.78 | 6.78 | 166.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | IC50 | 6.35 | 5.84 | 450.0 | 2 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | EC50 | 5.93 | 5.93 | 1174.9 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 5.92 | 5.92 | 1188.0 | 1 |
| Histamine H2 receptor CHEMBL1941 | Ki | 5.57 | 5.215 | 2683.0 | 2 |
| 5-hydroxytryptamine receptor 1B CHEMBL1898 | Ki | 5.46 | 5.46 | 3508.0 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 5.35 | 5.35 | 4446.0 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 5.19 | 5.19 | 6514.0 | 1 |
| Beta-2 adrenergic receptor CHEMBL210 | Ki | 4.0 | 4.0 | 100000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 90.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine