Assay Detail
Binding
CHEMBL883696
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Effective concentration against dopamine D3 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.79 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316983 | — | — | 1 | 8.96 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 8.82 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316983 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL301265 | PRAMIPEXOLE | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 2.6 | nM | 8.59 |