Assay Detail
Functional
CHEMBL942048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
50
Total Activities
47
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 47 | 7.47 | 9.00 |
| Emax | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 9.00 |
| CHEMBL155731 | QUINELORANE | 2.0 | 1 | 9.00 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 8.40 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 8.15 |
| CHEMBL250403 | — | — | 2 | 8.10 |
| CHEMBL102463 | — | — | 1 | 7.57 |
| CHEMBL250003 | — | — | 2 | 7.50 |
| CHEMBL401157 | — | — | 1 | 7.46 |
| CHEMBL250002 | — | — | 2 | 7.44 |
| CHEMBL399892 | — | — | 1 | 7.43 |
| CHEMBL249793 | — | — | 1 | 7.40 |
| CHEMBL249357 | — | — | 1 | 6.37 |
| CHEMBL251215 | — | — | 1 | 6.26 |
| CHEMBL401328 | — | — | 1 | 6.06 |
| CHEMBL398480 | — | — | 1 | 5.88 |
| CHEMBL401125 | — | — | 1 | - |
| CHEMBL251216 | — | — | 1 | - |
| CHEMBL401126 | — | — | 1 | - |
| CHEMBL248595 | — | — | 1 | - |
| CHEMBL251025 | — | — | 1 | - |
| CHEMBL249588 | — | — | 1 | - |
| CHEMBL251042 | — | — | 1 | - |
| CHEMBL400988 | — | — | 1 | - |
| CHEMBL248970 | — | — | 1 | - |
| CHEMBL249791 | — | — | 1 | - |
| CHEMBL249586 | — | — | 1 | - |
| CHEMBL250612 | — | — | 1 | - |
| CHEMBL249587 | — | — | 1 | - |
| CHEMBL251023 | — | — | 1 | - |
| CHEMBL251040 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL155731 | QUINELORANE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL589 | ROPINIROLE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL53 | APOMORPHINE | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL250403 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL102463 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL250003 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL401157 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL250002 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL399892 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL249793 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL249357 | — | EC50 | = | 427.0 | nM | 6.37 |
| CHEMBL251215 | — | EC50 | = | 547.0 | nM | 6.26 |
| CHEMBL401328 | — | EC50 | = | 864.0 | nM | 6.06 |
| CHEMBL398480 | — | EC50 | = | 1312.0 | nM | 5.88 |
| CHEMBL400988 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL249794 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL251023 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL250831 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL400987 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL250830 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL250829 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL399967 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL249792 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL250635 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL250634 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL400766 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL398696 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL101480 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL105646 | — | EC50 | > | 2800.0 | nM | - |
| CHEMBL250632 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL249997 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL251040 | — | EC50 | > | 688.0 | nM | - |
| CHEMBL250002 | — | Emax | > | 90.0 | % | - |
| CHEMBL249587 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL250612 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL249586 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL249791 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL248970 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL249588 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL251042 | — | EC50 | > | 5900.0 | nM | - |
| CHEMBL251216 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL251025 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL248595 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL250403 | — | Emax | > | 90.0 | % | - |
| CHEMBL401126 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL250003 | — | Emax | > | 90.0 | % | - |
| CHEMBL401125 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL250636 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL398694 | — | EC50 | > | 3000.0 | nM | - |