Compound Detail
CHEMBL589
ROPINIROLE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL589 |
| Name | ROPINIROLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | UHSKFQJFRQCDBE-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
13
Targets
42
Activities
3
Assay Types
1
PK Parameters
20
Publications
6
Known Names
7
Indications
Molecular Properties
260.4
MW (Da)
2.85
ALogP
2
HBA
1
HBD
32.3
PSA (Ų)
0.82
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1997 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Parkinson Disease Restless Legs Syndrome Cocaine-Related Disorders Fibromyalgia Stroke Unverricht-Lundborg Syndrome Hyperprolactinemia
ATC Classification
N04BC04
ropinirole
Level 1: NERVOUS SYSTEM
Level 2: ANTI-PARKINSON DRUGS
Activity Summary
EC50 22 meas. best 8.41
Ki 15 meas. best 8.54
IC50 5 meas. best 7.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | Ki | 8.54 | 7.7275 | 2.9 | 4 |
| D(2) dopamine receptor CHEMBL217 | Ki | 8.43 | 7.5767 | 3.7 | 3 |
| Dopamine receptor D2 and D3 CHEMBL2111342 | EC50 | 8.41 | 8.41 | 3.9 | 1 |
| D(3) dopamine receptor CHEMBL234 | EC50 | 8.4 | 8.025 | 4.0 | 4 |
| D(2) dopamine receptor CHEMBL217 | EC50 | 8.19 | 6.8708 | 6.5 | 12 |
| D(4) dopamine receptor CHEMBL219 | Ki | 8.11 | 8.11 | 7.8 | 1 |
| D(3) dopamine receptor CHEMBL3138 | Ki | 7.53 | 7.53 | 29.3 | 2 |
| Dopamine receptor D2 and D3 CHEMBL2111342 | IC50 | 7.25 | 6.63 | 56.1 | 2 |
| D(2) dopamine receptor CHEMBL339 | EC50 | 7.12 | 7.12 | 75.5 | 1 |
| Oryctolagus cuniculus CHEMBL374 | EC50 | 7.0 | 7.0 | 100.0 | 2 |
| Dopamine receptor CHEMBL2096905 | EC50 | 7.0 | 7.0 | 100.0 | 1 |
| D(3) dopamine receptor CHEMBL3138 | IC50 | 6.97 | 6.97 | 107.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | EC50 | 6.85 | 6.85 | 141.2 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 5.77 | 5.77 | 1706.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | IC50 | 5.74 | 5.74 | 1803.0 | 1 |
| D(2) dopamine receptor CHEMBL339 | Ki | 5.57 | 5.57 | 2674.0 | 2 |
| D(2) dopamine receptor CHEMBL3998 | IC50 | 5.17 | 5.17 | 6810.0 | 1 |
| D(1A) dopamine receptor CHEMBL2056 | Ki | 4.49 | 4.49 | 32500.0 | 1 |
| D(1B) dopamine receptor CHEMBL1850 | Ki | 4.38 | 4.38 | 41211.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 55.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine