Assay Detail
Binding
CHEMBL3880775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at dopamine D2 receptor short isoform (unknown origin) expressed in mouse NIH/3T3 cells by R-SAT assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH/3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.68 | 11.00 |
| pEC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 11.00 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 9.45 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 9.30 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.40 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 8.19 |
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 8.15 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.24 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL531 | PERGOLIDE | EC50 | = | 0.3548 | nM | 9.45 |
| CHEMBL493 | BROMOCRIPTINE | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL59 | DOPAMINE | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL589 | ROPINIROLE | EC50 | = | 6.457 | nM | 8.19 |
| CHEMBL301265 | PRAMIPEXOLE | EC50 | = | 7.079 | nM | 8.15 |
| CHEMBL53 | APOMORPHINE | EC50 | = | 575.44 | nM | 6.24 |
| CHEMBL39 | SEROTONIN | pEC50 | - | — | - |