Assay Detail
Binding
CHEMBL672313
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Binding affinity towards Dopamine receptor D2 by displacement of [3H]U-86170.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.86 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 1 | 9.30 |
| CHEMBL434665 | — | — | 1 | 8.60 |
| CHEMBL531 | PERGOLIDE | 4.0 | 1 | 8.40 |
| CHEMBL589 | ROPINIROLE | 4.0 | 1 | 8.14 |
| CHEMBL419792 | SUMANIROLE | 3.0 | 1 | 8.05 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 8.00 |
| CHEMBL422344 | — | — | 1 | 7.92 |
| CHEMBL348285 | — | — | 1 | 6.45 |
| CHEMBL345458 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL434665 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL531 | PERGOLIDE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL589 | ROPINIROLE | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL419792 | SUMANIROLE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL422344 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL348285 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL345458 | — | Ki | = | 1281.0 | nM | 5.89 |